Linhui Zhai
Member
Dr. Zhai earned his Ph.D. in Chinese Materia Medica from Nanjing University of Chinese Medicine (NJUCM) from September 2019 to March 2023. He served as an Associate Research Fellow at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS) from October 2022 to April 2024, and has been an Associate Professor at Tongji University since April 2024. He is currently an Associate Professor and Doctoral Supervisor at Tongji University School of Medicine. Dr. Zhai is a member of the Youth Committee of the Biochemical and Biotechnological Pharmaceuticals Specialty Committee, Shanghai Pharmaceutical Association. His research focuses on the mechanisms of metabolic diseases and tumors using proteomics and post-translational modification proteomics. He pioneered the first proteomic landscape of lung adenocarcinoma and discovered a series of novel biomarkers (Cell, 2020); comprehensively characterized the multidimensional molecular panorama and novel mechanisms of breast cancer–lymph node metastasis (Protein & Cell, 2026); revealed a novel negative regulatory mechanism of homologous recombination repair through RAD51 K285 succinylation in tumors (Mol Cell, 2026); and developed a photo-click chemistry-based technology for spatiotemporal dynamic analysis of lysine modification-regulating enzyme–substrate interactions (Nat Commun, 2024). As first or co-first author, he has published over 20 papers in journals including Cell, Mol Cell, Nat Commun, Protein Cell, Arthritis Rheumatol, Cancer Lett, Sci China Life Sci, Acta Pharmacol Sin, Genom Proteom Bioninf, and Mol Cell Proteomics. His research has been featured in China’s 2020 Important Medical Advances and the 2020 Shanghai Science and Technology Progress Report, and has been widely reported by domestic and international media including China Central Television (CCTV) and EurekAlert.
Selected publications:
1. Linhui Zhai#, Cui-Cui Liu#, Lei Zhao#, Le-Wei Zheng#, Chengyu Chu#, Hong Hu#, Yu-Wen Cai, Lie Chen, Yi-Ming Liu, Yiou Wang, Wensi Zhao, Yuqi Huang, Shiyu Duan, Zhi-Ming Shao, Yiting Jin*, Minjia Tan*, Ke-Da Yu*. Multi-omics Analysis Reveals Comprehensive Aberrant Protein and Phosphorylation Characteristics in Breast Cancer and Paired Metastatic Lymph Nodes. Protein & Cell, 2026 Jan 12:pwag002.
2. Zhe Wang#, Mingpeng Jin#, Linhui Zhai#, Bingsong Huang#, Xuan Jin, Xuanhe Wang, Ala Eddine Boudemia, Xiaoning Yang, Zhiting Wei, Yiming He, Jie Yang, Yunxuan Li, Xin Ding, Rui Li, Xuan Zhou, Wen Zheng, Yaobing Ouyang, Qianwen Wang, Yifei Song, Zhikai Zeng, Yu Li, Lu Lu, Jiaqi Liu, Yunhui Li, Lei Li, Ke Li, Chun-Long Chen, Zhenkun Lou, Minjia Tan*, Jinhuan Wu*, Yuping Chen*, Jian Yuan*. RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer. Mol Cell. 2026 Feb 19;86(4):585-603.
3. Hao Hu#, Wei Hu#, An-Di Guo#, Linhui Zhai#, Song Ma, Hui-Jun Nie, Bin-Shan Zhou, Tianxian Liu, Xinglong Jia, Xing Liu, Xuebiao Yao, Minjia Tan, Xiao-Hua Chen. Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells. Nature Communications, 2024, 15(1):1465.
4. Lin-hui Zhai#, Xing-long Jia#, Yu-lu Chen#, Mu-yin Liu#, Jing-dan Zhang#, Shao-jie Ma, Xiu-jun Wang, Wen-hao Cheng, Jing-liang He, Jiao-jiao Zhou, Ling-yi Zuo, Mei-qi Zhang, Qing Yuan, Menghan Xu, Jing Ji, Min-jia Tan*, Bin Liu*. Comprehensive multi-omics analysis elucidates colchicineinduced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors. Acta Pharmacologica Sinica, 2025, 46(3):702-714.
5. Jun-Yu Xu#, Chunchao Zhang#, Xiang Wang#, Linhui Zhai#, Yiming Ma#, Yousheng Mao, Kun Qian, Changqing Sun; Zhiwei Liu; Shangwen Jiang; Minghui Wang; Lin Feng; Lei Zhao, Ping Liu, Bo Wang, Xin Zhao, Hui Xie, Xiaoyun Yang, Liyuan Zhao, Yafei Chang, Jingya Jia, Xijun Wang, Yimin Zhang, Yaru Wang, Yikun Yang, Zhixiang Wu, Longhai Yang, Bin Liu, Teng Zhao, Shengguo Ren, Aihua Sun, Yang Zhao, Wantao Ying, Fei Wang, Guangshun Wang, Yi Zhang, Shujun Cheng, Jun Qin, Xiaohong Qian, Yi Wang*, Jing Li*, Fuchu He*, Ting Xiao*, Minjia Tan*. Integrative proteomic characterization of human lung adenocarcinoma. Cell, 2020, 182(1): 245-261.