王嘉希

王博士于2013年9月至2018年6月在复旦大学分析化学专业攻读博士学位；2018年7月至2020年11月在复旦大学从事博士后研究；2020年12月起在复旦大学任副研究员。自2025年起，王博士任Journal of Analysis and Testing期刊青年编委一职。王博士聚焦多维色谱分离在糖基化蛋白质组学中的应用，重点在于通过功能化材料高效富集糖基化蛋白/肽段，结合多维色谱串联体系进行深度分离，大幅降低样本复杂度，有效解决糖肽丰度低、鉴定难的瓶颈。特色在于将材料富集、高效色谱分离与质谱鉴定深度融合，建立“材料富集-多维分离-质谱采集-生物信息解析”一体化分析流程，显著提升糖基化位点鉴定通量与解析能力。其意义在于，糖基化作为关键翻译后修饰，广泛参与细胞识别、免疫应答及肿瘤发生，材料富集与多维色谱技术的协同介入突破了糖基化蛋白质组深度覆盖的技术瓶颈，为系统解析疾病状态下的糖基化异质性、筛选新型生物标志物、阐明相关调控机制提供了关键方法学支撑，推动精准修饰组学向临床转化应用。

代表作：
1. Jiaqi Wu, Shuangshuang Liu, Wei Dan, Xiao Tong, Jingyi Gong, Zimeng Li, Yu Gu, Jindian Xu, Weiwei Chen, Shupei Wang, Xue-Yang Luo, Huanya Yang, Yingli Jia, Chih-Hao Chang, Kexiang Yan*, Jiaxi Wang*, Li-Hao Huang*. Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages. Cell Metabolism. 2026 18: S1550-4131(26)00057-4.
2. Bing Li, Qunfei Tai, Hailong Yu, Jiaxi Wang*, Mingxia Gao, Xiangmin Zhang*. Nanoliter plasma sample for disease diagnosis by using a visualization platform of counting extracellular vesicle particles. Analytical Chemistry. 2025, 11;97(5):2786-2794.
3. Weiwei Chen, Jindian Xu, Huanya Yang, Yingli Jia, Hua Bian, Li-Hao Huang*, Jiaxi Wang*. Developing a Two-Dimensional Size-Exclusion Liquid Chromatography Platform for Isolating the High-Quality Extracellular Vesicles to Predict and Evaluate Metabolic Improvement Outcomes of Sleeve Gastrectomy. Analytical Chemistry. 2025, 15;97(27):14435-14445.
4. Xiao Tong, Weiwei Chen, Yan Xia, Yanmei Wang, Shuangshuang Liu, Yingli Jia, Jiaxi Wang*, Li-Hao Huang*. Glycoproteomics analysis to identify potential biomarkers and investigate CD14+ monocyte activation mechanisms via exosomal proteins in cerebral infarction using a novel glycogen-functionalized nanoprobe. Analytical Chemistry. 2025, 22;97(28):14943-14955.
5. Jia Liu, Mengran Li, Qiuhong Man*, Li-Hao Huang, Jiaxi Wang*, Mingxia Gao, Xiangmin Zhang*. Naked-eye readout distance quantitative lateral flow assay based on the permeability changes of enzyme-catalyzed hydrogelation. Analytical Chemistry. 2023, 23;95(20):8011-8019.