Ping Xu

Professor Xu Ping focuses on post-translational modifications of proteins, high-coverage precision quantitative proteomics, and precision medicine research based on proteomics. He has led and completed major projects including the “973” project “Quantitative Proteomics Study of Protein Post-translational Modifications in Liver Disease Development” and the National Precision Medicine Major Project “Research on Precise, Specific, Sensitive and Practical Clinical Quantitative Proteomics Support Technology.” Internationally, he established the first protein ubiquitination macro and micro heterogeneity analysis technology system based on de novo protein sequencing, absolute quantification of ubiquitin chains, and false positive exclusion technology for ubiquitinated proteins. He pioneered the quantification of cellular ubiquitin chain composition, dividing seven types of ubiquitin chains into two groups: non-K63 ubiquitin chains that dominate protein degradation and K63 ubiquitin chains for non-protein degradation, internationally referred to as “Chain gang.” He discovered two new signaling pathways: K11 ubiquitin chain-guided protein degradation and regulation of transcription factor switch methionine synthesis. He has published over 160 research papers in Cell, Gastroenterology, Molecular Cell, Nature Communications, etc.; holds 55 authorized invention patents, 6 commercialized products, and one marketed national new drug from genetic engineering. He has received multiple research awards including Shijiazhuang Science and Technology Progress First Prize, National Economic and Trade Commission Outstanding Technological Innovation Project Award, Yunnan Province Natural Science First Prize, National Proteomics Innovation Team, and China Invention Association Invention and Innovation Award Second Prize.

1. Tao Zuo,# Qi Xie,# Jinfang Liu,# Jing Yang,# Jiahui Shi,# Degang Kong,# Yin Wang,#et al and Ping Xu*, Macrophage-derived cathepsin S remodels the extracellular matrix to promote liver fibrogenesis, Gastroenterology
2. Shu-Kun Tang#，*, Xiao-Yang Zhi#, Yao Zhang#, Kira-S. Makarova#, Bing-Bing Liu#, et al , Ping Xu*, Cellular differentiation into hyphae and spores in halophilic archaea, Nat Communication, 2023
3. Qing Ye#, Jia Zhou#, Qi He#, Rui-Ting Li#, Guan Yang#, et al, Ping Xu*, SARS-CoV-2 infection in the mouse olfactory system, Cell Discovery, 2021, 7(1):49.