Jinke Cheng

Research Interests:
1. Protein SUMO modification and mitochondrial metabolism regulation, studying the regulatory effects and mechanisms of SUMO modification of mitochondrial proteins on mitochondrial metabolic activity and its impact on cellular function;
2. Protein SUMO modification and tumor metabolism and inflammatory response regulation, investigating the regulatory role of protein SUMO modification on tumor metabolism and inflammatory cell activity and its significance in inflammation-related diseases;
3. Protein SUMO modification and aging mechanism research, studying the role and significance of the SENP1-Sirt3 axis in human physiological and pathological processes.

He, J., Shangguan, X., Zhou, W., Cao, Y., Zheng, Q., Tu, J., Hu, G., Liang, Z., Jiang, C., Deng, L., Wang, S., Yang, W., Zuo, Y., Ma, J., Cai, R., Chen, Y., Fan, Q., Dong, B., Xue, W., Tan, H., … Cheng, J. (2021). Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nature communications, 12(1), 4371.