田志新 Zhixin Tian

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目前主要研究领域是基于质谱的蛋白质组学与糖基化修饰组学新技术新方法研发及应用研究。发明了生物质谱原位解析算法”同位素质荷比及轮廓指纹比对，iMEF”，并基于iMEF算法发展了完整蛋白质、磷酸化多肽、N-连接糖、完整N-糖肽、糖脂、糖核酸的位点和结构特异定性定量分析新技术新方法；并在癌症潜在生物标志物的发现、生物药表征、物种糖基化草图构建等领域开展了应用研究。在Chemical Communications, Analytical Chemistry, Analytica Chimica Acta, Analytical and Bioanalytical Chemistry, Journal of Proteomics, Scientific Reports, Chemical Reviews等刊物上发表论文90余篇。研究方向：1. 生物质谱新技术新方法；2. 位点和结构特异定量糖蛋白质组学、糖脂质组学及糖核酸组学新技术新方法；3. 疾病异常糖基化修饰的发现及验证。

Current main research field is the development and application of new technologies and methods in mass spectrometry-based proteomics and glycosylation modification omics. Invented the biological mass spectrometry in-situ analysis algorithm “isotope mass-to-charge ratio and profile fingerprint comparison, iMEF”, and based on the iMEF algorithm, developed new technologies and methods for site- and structure-specific qualitative and quantitative analysis of intact proteins, phosphorylated peptides, N-linked glycans, intact N-glycopeptides, glycolipids, and glyconucleic acids; and conducted application research in fields such as discovery of potential cancer biomarkers, biopharmaceutical characterization, and construction of species glycosylation blueprints. Has published over 90 papers in journals such as Chemical Communications, Analytical Chemistry, Analytica Chimica Acta, Analytical and Bioanalytical Chemistry, Journal of Proteomics, Scientific Reports, and Chemical Reviews. Research directions: 1. New technologies and methods in biological mass spectrometry; 2. New technologies and methods for site- and structure-specific quantitative glycoproteomics, glycolipidomics, and glyconucleic acid omics; 3. Discovery and validation of disease-related abnormal glycosylation modifications.

1. Suideng Qin, Zhixin Tian*. Gain-of-glycosylation in breast multi-drug-resistant MCF-7 adenocarcinoma cells and cancer stem cells characterized by site- and structure-specific N-glycoproteomics. Analytica Chimica Acta, 2023, 1252, 341029.
2. Yanqiu Gong#, Suidong Qin#, Lunzhi Dai*, Zhixin Tian*. The glycosylation in SARS-CoV-2 and its receptor ACE2. Signal Transduction and Targeted Therapy (invited review), 2021, 6 (1), 396.