张雪

委员

张博士于2017年8月至2022年6月在天津医科大学药学专业攻读博士学位;2022年7月至2024年6月在北京大学从事博士后研究;2024年6月起在上海大学任助理研究员。张博士现任Pharmaceutical Science Advances期刊青年编委。张博士主要从事微流控芯片样品预处理平台构建及芯片-质谱在线联用的单细胞蛋白质组学分析方法开发,聚焦蛋白质及翻译后修饰肽的高效分离富集研究。核心特色在于:(1)将功能化毛细管整体柱(二氧化钛掺杂柱、乙酰化分子印迹柱、星型硼亲和柱等)与微流控芯片深度整合,构建蛋白质分级-酶解-乙酰化肽/糖肽富集多功能在线平台;(2)设计微流控芯片-nanoLC-MS全流程联用系统,完成单细胞样品的快速预处理与高灵敏检测,显著提升单细胞水平的蛋白质组学的质谱鉴定深度。以第一作者在Trends in Analytical Chemistry、Analytical Chemistry、Journal of Proteome Research、Analytica Chimica Acta等期刊发表SCI论文,授权国家发明专利3项。主持国家自然科学基金青年基金、北京分子科学国家研究中心博士后项目等。

 

代表作:
1. Xue Zhang#, Fenghua Xu#, Rui Wu#, Huiying Zhang, Yufei Shi, Zhaosheng Liu*, Xin Dong*, Green preparation of graphene oxide-incorporated monoliths for pH-controlled protein enrichment and clinical biomarker detection, Analytica Chimica Acta, 1397, 2026, 345266.
2. Xue Zhang, Fenghua Xu, Yufei Shi, Huiying Zhang, Xin Dong, Yu Bai*, Multifunctional microfluidic chips in single-cell analysis: design, integration and omics application, TrAC Trends in Analytical Chemistry, 2026, 195: 118554.
3. Xue Zhang, Qin Wei, Xin Meng, Lili Zhao, Zhaosheng Liu*, Yanping Huang*. Boronate Avidity Assisted by Dendrimer-like Polyhedral Oligomeric Silsesquioxanes for a Microfluidic Platform for Selective Enrichment of Ubiquitination and Glycosylation. Analytical Chemistry, 2023, 95:1241-1250.
4. Xue Zhang, Yang Wang, Zehui Wei, Dongyu An, Wanrong Pu, Zhaosheng Liu*, Yanping Huang*, Improving identification of lysine acetylated peptides using molecularly imprinted monolith prepared by a deep eutectic solvents monomer. Journal of Proteome Research, 2022, 21:325-338.
5. Xue Zhang#, Meihong Chai#, Zehui Wei, Wenjing Chen, Zhaosheng Liu*, Yanping Huang*, Deep eutectic solvents-based polymer monolith incorporated with titanium dioxide nanotubes for specific recognition of proteins. Analytica Chimica Acta, 2020, 1139:27-35.