程金科 Jinke Cheng

研究方向:1. 蛋白质SUMO修饰与线粒体代谢调控,研究线粒体蛋白的SUMO修饰对线粒体代谢活性的调控作用与机制以及对细胞功能的影响;2. 蛋白质SUMO修饰与肿瘤代谢及炎症反应调控,研究蛋白质SUMO修饰对肿瘤代谢及炎症细胞活性的调控作用以及在炎症相关疾病中的意义;3. 蛋白质SUMO修饰与衰老机制研究,研究SENP1-Sirt3轴在人生理与病理过程中的作用与意义。

Research Interests: 1. Protein SUMO modification and mitochondrial metabolism regulation, studying the regulatory effects and mechanisms of SUMO modification of mitochondrial proteins on mitochondrial metabolic activity and its impact on cellular function; 2. Protein SUMO modification and tumor metabolism and inflammatory response regulation, investigating the regulatory role of protein SUMO modification on tumor metabolism and inflammatory cell activity and its significance in inflammation-related diseases; 3. Protein SUMO modification and aging mechanism research, studying the role and significance of the SENP1-Sirt3 axis in human physiological and pathological processes.

He, J., Shangguan, X., Zhou, W., Cao, Y., Zheng, Q., Tu, J., Hu, G., Liang, Z., Jiang, C., Deng, L., Wang, S., Yang, W., Zuo, Y., Ma, J., Cai, R., Chen, Y., Fan, Q., Dong, B., Xue, W., Tan, H., … Cheng, J. (2021). Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nature communications, 12(1), 4371.