邓海腾 Haiteng Deng

研究方向:发展和应用蛋白质组学、代谢组学和化学生物学的技术和方法。研究氧化还原生物学在衰老和疾病中的功能和作用机制。发展衰老及其疾病相关的生物标志物。开发提高健康寿命的天然小分子、纳米抗体和疫苗。研究病原微生物-宿主细胞的相互作用。鉴定肿瘤早期诊断的标记物并研究蛋白质药物的修饰和作用机制。

Research Interests: Developing and applying technologies and methods in proteomics, metabolomics, and chemical biology. Investigating the functions and mechanisms of redox biology in aging and diseases. Developing biomarkers related to aging and associated diseases. Discovering natural small molecules, nanobodies, and vaccines that improve healthspan. Studying pathogen-host cell interactions. Identifying markers for early tumor diagnosis and investigating the modification and mechanisms of protein therapeutics.

Wang T, Yang C, Li Z, Li T, Zhang R, Zhao Y, Cheng T, Zong Z, Ma Y, Zhang D, Deng H., Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy, Redox Biol. 2024 Feb;69:103017.

Yingying Ma; Meiqi Yi; Weixuan Wang; Xiaohui Liu; Qingtao Wang; Chongdong Liu; Yuling Chen; Haiteng Deng; Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility, Cell Death & Disease, 2022, 13(11): 944-953.

Wang W, Yang C, Wang T, Deng H., Complex roles of nicotinamide N-methyltransferase in cancer progression, Cell Death Dis. 2022 Mar 25;13(3):267.

Songbiao Zhu; Wenxi Ding; Yuling Chen; Weixuan Wang; Renhua Xu; Chongdong Liu; Xiaohui Liu; Haiteng Deng, High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumour Cells, Genomics, Proteomics & Bioinformatics, 2021 Feb 26:S1672-0229.

Yang C, Zhu S, Chen Y, Liu Z, Zhang W, Zhao C, Luo C, Deng H., Flavonoid 4,4′-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation. Free Radic Biol Med. 2021 Nov 1; 175:206-215.