Yingrui Wang

Dr. Wang earned her Ph.D. in Biology from Tsinghua University from September 2013 to July 2019. She then served as an Assistant Research Fellow under the Outstanding Talent Program at the Yangtze Delta Region Institute of Tsinghua University, Zhejiang, from July 2019 to December 2020. She conducted postdoctoral research and served as an Assistant Research Fellow in the laboratory of Professor Tiannan Guo at Westlake University from January 2021 to January 2023. She then joined Westlake Laboratory of Life Sciences and Biomedicine (Zhejiang Provincial Laboratory of Life Sciences and Biomedicine) from January 2023, serving as an Assistant Research Fellow and then as an Associate Research Fellow. Since January 2026, she has been an Associate Research Fellow at Westlake University. Dr. Wang has been serving as an Editorial Board Member of the first Editorial Committee of the Anti-Aging Medicine special issue of the Medical Reference since 2025. Dr. Wang’s research focuses on proteomics-driven precision medicine, distinguished by the deep integration of high-throughput proteomics with machine learning to address real-world clinical challenges. Her research emphasizes: elucidating immune dynamics and predicting antibody persistence following COVID-19 vaccination through longitudinal proteomics (Protein & Cell); constructing a blood multi-omics atlas of Omicron infection to predict the risk of viral rebound (Immunity, selected as one of the Top 10 Advances in Chinese Hematology); and integrating multi-center proteomic data with machine learning to establish individualized prognostic models for medullary thyroid carcinoma (Nature Communications). Additionally, she has contributed to revealing the multi-organ mechanisms of protein restriction in delaying aging (Cell) and to the clinical translation of precision diagnosis and treatment for thyroid diseases. Recently, she has also ventured into the understudied proteome. Her work provides novel protein biomarkers and predictive models for optimizing vaccination strategies and precision oncology, advancing the translation of proteomics from molecular discovery to clinical application.

Selected publications:
1. Yingrui Wang#, Qianru Zhu#, Rui Sun#, Xiao Yi#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao, Yantao Li, Jie Li*, Tiannan Guo*, Junping Shi*. Longitudinal proteomic investigation of COVID-19 vaccination. Protein&Cell, 2023, 14(9): 668-682.
2. Yan Zhou#, Yingrui Wang#, Xiao Shi#, Jiatong Wang#, Zelin Zang#, Likun Zhang#, Zhiqiang Gu, Xue Cai, Pingping Hu, Jiaxi Wang, Hanqing Liu, Zhihong Wang, Haixia Guan, Xiaohong Wu, Cenkai Shen, Yi He, Mo Li, Hao Zhang, Jianbiao Wang , Yijun Wu, Chuang Chen , Yi Zhu, Yaoting Sun*, Zhiyan Liu*, Yu Wang*, Tiannan Guo *. Multi-center multi-omics integration predicts individualized prognosis in medullary thyroid cancer. Nature Communications, 2026, 17, 432.
3. Hong Wang*,#, Cuicui Liu#, Xiaowei Xie#, Mingming Niu#, Yingrui Wang#, Xueliang Cheng#, Biao Zhang#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma , Huijun Wang, Guoqing Zhu, Yang Lu,Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentao Jiang, Ximo Wang∗, Zhongyang Shen∗, Tiannan Guo∗, Jiaxi Zhou∗, Ping Zhu∗, Tao Cheng∗. Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection. Immunity, 2023, 56(6): 1410-1428. (2023 Top Ten Best Achievements in Chinese Hematology Research )
4. Lu Li#, Wenhao Jiang#, Wenjun Wei, Gnana P Krishnamoorthy, Pingping Hu, Mengni Chen, Vera Tiedje, Adrián Acuña-Ruiz, He Wang, Zhihong Wang, Jianbiao Wang, Hanqing Liu, Wanyuan Chen, Haixia Guan, Chuang Chen, Hao Zhang, Yu Wang, James A Fagin, Tiannan Guo, Yi Zhu, Yingrui Wang*, Jianqing Gao*, Yaoting Sun*.Comprehensive Mass Spectral Libraries of Human Thyroid Tissues and Cells. Scientific Data, 2024,11(1):1448.
5. Tian Lu#, Yuting Xie#, Yingrui Wang, Xiling Lin, Xue Cai, Yuqi Zhang, Zongxiang Nie, Chang Su, Wanglong Gou, Hong Zhang, Jing Wang, Yan Zhong, Zeyin Lai, Jingjing Xiang, Peng-Fei Shan, Ju-Sheng Zheng, Huijun Wang, Yi Zhu*, Tiannan Guo*. Protein restriction reprograms the multi-organ proteomic landscape of mouse aging. Cell, 2025,188(25):7309-7326.e20.