Wenhao Shi

Dr. Shi graduated from the School of Life Sciences at Tsinghua University. During his doctoral studies, he conducted proteomics research at the National Center for Protein Sciences (Beijing) (NCPSB). He pursued postdoctoral research at the Department of Chemistry, Tsinghua University, and subsequently joined the university‑level testing platform at the Analysis Center of Tsinghua University, where he established and operated a proteomics laboratory. Dr. Shi currently serves as a council member of the Youth Committee of the Beijing Association for Physicochemical Analysis and Testing. He has led multiple research projects, including the Young Scientists Fund of the National Natural Science Foundation of China, the China Postdoctoral Science Foundation General Grant, and the Tsinghua University Laboratory Innovation Fund. He has published numerous proteomics research papers in international journals such as Nature Communications, Advanced Science, and Angewandte Chemie International Edition. Dr. Shi is dedicated to advancing cutting‑edge mass spectrometry technologies to support precision diagnosis and treatment of clinical tumors as well as fundamental life science research. He has successively mapped the proteomic landscapes of gastric cancer in the Chinese population, pan‑cancer cell lines, and lung cancer exosomes, systematically revealing tumor molecular characteristics and heterogeneity patterns, thereby facilitating precision medicine research and clinical translation.

Selected publications:
1. Shi Wenhao, Wang Yushen, Xu Chen, Li Yan, Wang Yi, Chen Lin, Zhao Qingchuan, Shen Lin, He Fuchu, Qin Jun, and Ding Chen*. Multilevel proteomic analyses reveal molecular diversity between diffuse type and intestinal-type gastric cancer[J]. Nature Communications, 2023.
2. Shi Wenhao, He Tianlong, Wang Nan, Annan Qian, Yuqiao Liu, Tang Shaojun, and Zhu Yiying*. Integrated multi-dimensional comparison of proteomic profiles across 54 cancer cell lines[J]. iScience, 2025.
3. Zhao Chuangyuan, Shi Wenhao, Li Xiaowei, Ying Yang, Jin Yu, Dong Guizhi, Liu Dongsheng, and Dong Yuanchen*. Site-Specific and Regioselective Modification of Human Epidermal Growth Factor Receptor 2 via Site-Sculpted DNA Nanorefiners[J]. Angewandte Chemie International Edition, 2025.
4. Lin Caishi, Shi Wenhao, Zhu Yanfei, Ma Weiheng, Ai Yongjian, Wang Jing, Liang Qionglin, and He Mengqi. Atomic iron-engineered dual-modal nanozyme enhances tumor-targeted chemodynamic/photothermal synergistic therapy[J]. Nano Research, 2025.
5. Pu Yan, Wan Yi, Shi Wenhao, Li Bin, Zhang Haiyue, Wu Jun, Li Lingling, Guo Wenjia, Ding Chen, Yang Wenjun. TEAD1 enhances exosome secretion and promotes exosome-mediated tissue regeneration[J]. Advanced Science, 2026.