Tian Sang

Dr. Sang earned her Ph.D. in Biology and Molecular Biology from the Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, from September 2016 to June 2022. She conducted postdoctoral research at the Institute of Advanced Biotechnology, Southern University of Science and Technology (SUSTech), from July 2022 to September 2024, and has been a Research Assistant Professor at the same institute since October 2024. Dr. Sang’s research focuses on plant proteomics and post-translational modification proteomics: (1) To address the challenge of SUMOylation site identification, she innovatively developed a high-sensitivity mass spectrometry method based on a lysine-deficient mutant (K0-SUMO1), achieving the first precise identification of modification sites at the proteomic level and constructing the largest SUMOylation site database in Arabidopsis thaliana to date, providing key technological resources for studying the functions of this modification in growth, development, and stress responses; (2) She established a plant single-cell proteomics system, achieving deep proteomic profiling of trace amounts of guard cells and revealing the basis of cell-type-specific signal transduction. Concurrently, she employed DIA phosphoproteomics to dissect early phosphorylation events upon osmotic stress and constructed an interactive kinase database, AtKinMap, providing an important platform and clues for research on plant signal transduction networks. Her related findings have been published in journals including Molecular & Cellular Proteomics and Plant Communications.

Selected publications:
1. Tian Sang*; Yaping Xu; Guochen Qin; Shasha Zhao; Chuan-Chi Hsu; Pengcheng Wang#; Highly sensitive site-specific SUMOylation proteomics in Arabidopsis, Nature Plants, 2024, 10(9)
2. Sang, Tian*; Chen, Chin-Wen; Lin, Zhen; Ma, Yu; Du, Yanyan; Lin, Pei-Yi; Hadisurya, Marco; Zhu, Jian-Kang; Lang, Zhaobo; Tao, W. Andy; Hsu, Chuan-Chih#; Wang, Pengcheng#; DIA-Based Phosphoproteomics Identifies Early Phosphorylation Events in Response to EGTA and Mannitol in Arabidopsis, MOLECULAR amp; CELLULAR PROTEOMICS, 2024, 23(8)
3. Yang, Linling*; Yuan, Boxuan; Fang, Fengyan; He, Minmin; Li, Wei; Hui, Shugang; Du, Xiaoyu; He, Lixia; Lui, Huijiao; Sang, Tian#; Wang, Xuchu#; Integrated proteomic and phosphoproteomic analysis reveals the MAPK cascade as a key regulator of ethylene-induced latex production in Hevea brasiliensis, Stress Biology, 2026, 6(1): 18-18
4. Tian Sang*; Zhen Zhang; Guting Liu; Pengcheng Wang#; Navigating the Landscape of Plant Proteomics, Journal of Integrative Plant Biology, 2025, 740-761
5. Chen Zhu*; Tian Sang*; Zhen Zhang; Yubei Wang; Zhen Lin; Wei Wang; Zhaobo Lang; Jian‐Kang Zhu; Pengcheng Wang#; Maintaining basal B‐RAF kinase activity for abscisic acid signaling via reciprocal phosphoregulation of a single serine residue, Journal of Integrative Plant Biology, 2025, 67(11): 2848-2862