Mingwei Sun

Dr. Sun earned his Ph.D. in Pharmacology from the University of Chinese Academy of Sciences from September 2012 to June 2017. He conducted postdoctoral research at the Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), from August 2017 to September 2019. He served as an Assistant Research Fellow and then Associate Research Fellow at Bioland Laboratory from October 2019 to June 2025. Since July 2025, he has been an Associate Research Fellow at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences. Dr. Sun has long been engaged in methodological innovation in mass spectrometry-based proteomics, with a focus on high-throughput and precise analytical strategies for protein post-translational modifications (PTMs) and high-throughput single-cell proteome analysis. Targeting key PTMs including lysine methylation, ubiquitination, SUMOylation, and protein N-terminal modifications, he has established high-sensitivity enrichment and identification workflows to overcome the technical bottleneck of large-scale analysis of low-abundance modification sites. Concurrently, he has developed high-throughput LC-MS analytical systems suitable for trace samples and single-cell scales. Building on these methodologies, he integrates proteomics and metabolomics strategies to dissect the molecular mechanisms of skeletal muscle–adipose tissue crosstalk in chronic metabolic diseases and skeletal muscle degenerative disorders, identify potential drug targets, and elucidate functional pathways, achieving a seamless integration from methodological innovation to disease mechanism elucidation and drug development applications.

Selected publications:
1. Sun M, Qiao Z, Wei S, Liang Z, Zhang L, Jiang B, Zhang Y. Global Methylation Profiling by Selective Release of Methylated Sites from Immobilized Tryptic Peptides. Analytical Chemistry, 2025, 97(18): 9620-9626.
2. Sun M, Wei S, Li Y, Qiao Z, Liang Z, Shan Y, Zhang Y, Jiang B, Zhang L. Utilizing a Negative Enrichment Strategy to Profile Protein Methylation, Leveraging the Orthogonality of LysargiNase and Trypsin. Molecular & Cellular Proteomics, 2025, 100970.
3. Sun M, Zhang Q, Huang Q, Wu W, Zhang L, Zhang X. Antibody-free approach for ubiquitination profiling by selectively clicking the ubiquitination sites. Analytica Chimica Acta, 2023, 1246: 340877.
4. Hu X, Sun M, Chen Q, Zhao Y, Liang N, Wang S, Yin P, Yang Y, Lam SM, Zhang Q, Tudiyusufu A, Gu Y, Wan X, Chen M, Li H, Zhang X, Shui G, Fu S, Zhang L, Tang P, Wong CCL, Zhang Y, Zhu D. Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning. Nature Communications, 2023, 14(1): 7916.
5. Sun M, Zhang X. Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture. Cell and Bioscience, 2022, 12(1): 126.