Ming Tong

Dr. Tong earned his Bachelor of Science in Chemical Biology from Tsinghua University from September 2011 to June 2015. He pursued doctoral studies in Chemistry at the Georgia Institute of Technology (Georgia Tech) from September 2015 to December 2020, earning a Ph.D. degree. Since January 2021, he has been working at the Novo Nordisk Research Center China (NNRCC), where he has served as Scientist and subsequently Senior Scientist. During his doctoral studies, his research focused on mass spectrometry-based proteomics. He developed novel methods integrating metabolic labeling, click chemistry, and quantitative proteomics to systematically investigate the degradation pathways of newly synthesized proteins in human cells; established novel mass spectrometry methods for dynamic monitoring of protein synthesis rates; and participated in site-specific analyses related to glycoproteomics. As a Senior Scientist at Novo Nordisk, he has led the establishment of an automated proteomics platform, achieving high-throughput sample preparation and data acquisition for proteomics, modificomics, and secretomics, and built a cloud-based proteomics data processing and management system. He has coordinated large-scale proteomics data collection from in vivo and in vitro models to support metabolic disease target discovery and validation, biomarker research, automated target screening, and machine learning model development. He has been deeply involved in large-cohort multi-omics studies and translational research, and serves as a bioanalytical scientist in pipeline projects, guiding the screening and development of pharmacokinetic (PK) properties of drug candidates.

Selected publications:
1. Systematic quantification of the dynamics of newly synthesized proteins unveiling their degradation pathways in human cells, M Tong, JM Smeekens, H Xiao, R Wu, Chemical Science, 11 (13), 3557–3568, 2020
2. Effective method for accurate and sensitive quantitation of rapid changes of newly synthesized proteins, M Tong, S Suttapitugsakul, R Wu, Analytical Chemistry, 92 (14), 10048–10057, 2020
3. Global quantification of newly synthesized proteins reveals cell type- and inhibitor-specific effects on protein synthesis inhibition, K Yin, M Tong, S Suttapitugsakul, S Xu, R Wu, PNAS Nexus, 2 (6), pgad168, 2023
4. Time-resolved and comprehensive analysis of surface glycoproteins reveals distinct responses of monocytes and macrophages to bacterial infection, S Suttapitugsakul, M Tong, R Wu, Angewandte Chemie, 133 (20), 11595–11604, 2021
5. Spatial and temporal proteomics reveals the distinct distributions and dynamics of O-GlcNAcylated proteins, S Xu, M Tong, S Suttapitugsakul, R Wu, Cell Reports, 39 (11), 2022