Jing Yang

Dr. Yang earned her Ph.D. in Chemistry from Nanjing University from September 2021 to June 2025. Since September 2025, she has been a Postdoctoral Researcher at China Pharmaceutical University. Dr. Yang’s research focuses on protein structure and function analysis, protein engineering, and related detection technologies, with particular emphasis on biomolecular interaction mechanisms, genetic code expansion-mediated precise protein modification, and the structural and functional characterization of nanopore and CRISPR-associated systems. She has published representative work in Angewandte Chemie International Edition, Science China: Life Sciences, and Nature, including: establishing a nanopore site-specific bioorthogonal modification method, providing a new strategy for precise protein labeling and single-molecule detection; solving the crystal structure of Cas1 in complex with branched DNA, revealing key recognition mechanisms; and participating in the discovery of anti-CRISPR molecules that disassemble CRISPR-Cas complexes, deepening the understanding of protein complex regulatory mechanisms. Her work combines methodological innovation with mechanistic insights, providing important support for proteomic analysis, molecular diagnostics, and biotechnological applications.

Selected publications:
1. Yang J#; Wang K#, et al. Site-Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion. Angew. Chem. Int. Ed., 2023, 62(21): e202216115.
2. Yang J#, Li J#, et al., Crystal structure of Cas1 in complex with branched DNA. Science China: Life Sciences, 2019, 62, 1-13.
3. Chantel N. Trost, Yang J, et al., An anti-CRISPR that pulls apart a CRISPR-Cas complex, Nature, 2024, 632, 375-382.
4. Sun W#, Yang J#, Cheng Z#, et al., Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol Cell, 2019, 76, 938-952.