王建 Jian Wang

王建，教授、博士生导师，现任军事医学研究院生命组学研究所研究员。长期从事蛋白质相互作用组学和疾病分子机制研究，绘制了人类第一个器官（肝脏）蛋白质相互作用网络图，为肝脏疾病的发生发展机制及诊断标志物、治疗靶点的发现奠定了基础；系统解析了新冠病毒、手足口病毒等病原体与宿主相互作用网络，并揭示了炎症、肿瘤等重大疾病的分子调控机制。在 Mol Syst Biol、Nat Commun、PNAS、EMBO J、Nucleic Acids Res、Cell Chem Biol 等国际期刊发表论文80余篇，主持国家重点研发计划、863计划和国家自然科学基金等项目，获国家科技进步创新团队奖、北京市科技进步一等奖等多项奖励。研究方向：蛋白质组学与疾病分子机制。

Professor Jian Wang, PhD supervisor, currently a researcher at the Institute of Life Omics, Academy of Military Medical Sciences. Has long been engaged in protein interaction omics and disease molecular mechanism research, mapping the first human organ (liver) protein interaction network, laying the foundation for the discovery of liver disease development mechanisms, diagnostic markers, and therapeutic targets; systematically analyzed the interaction networks between pathogens such as SARS-CoV-2 and hand-foot-mouth disease virus with hosts, and revealed the molecular regulatory mechanisms of major diseases such as inflammation and tumors. Has published over 80 papers in international journals including Mol Syst Biol, Nat Commun, PNAS, EMBO J, Nucleic Acids Res, Cell Chem Biol, and has led projects including the National Key R&D Program, 863 Program, and National Natural Science Foundation, receiving multiple awards including the National Science and Technology Progress Innovation Team Award and Beijing Science and Technology Progress First Prize. Research Interest: Proteomics and disease molecular mechanisms.

代表论文
1. Zhang Y, Shang L, Zhang J, …, Wang J#. An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Cell Chem Biol. 2022, 29(1):5-18.
2. Shang L, Zhang Y, Liu Y, …, Wang J#. A yeast BiFC-seq method for genome-wide interactome mapping. Genomics Proteomics Bioinformatics. 2022, 20(4):795-807.
3. Wei J, Yuan Y, Chen L, …, Wang J#, He F#. ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes. Nat Commun. 2018, 9(1):3659.
4. Wei J, Wei C, Wang M, …, Wang J#, Yang X#, He F#. The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling. PNAS. 2014, 111(24):8883-8.
5. Wang J*, Huo K*, Ma L*, …, He F#, Yang X#. Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011;7:536.