姜颖 Ying Jiang

主要科研领域与方向：主要研究方向为肝脏蛋白质组，学术思路是通过解析肝脏在不同生理病理状态下的蛋白质组构成及其动态变化，以阐释肝脏的生理规律，确定肝脏疾病诊治的关键环节。对健康成人肝脏、胎肝及重大肝病的蛋白质组进行系统解析。取得了系列原创成果：1）构建了早期肝细胞癌人群队列的多组学数据库，首次实现了早期肝细胞癌的蛋白质组分子分型并发现其精准治疗的新靶标，开启了蛋白质组学驱动的精准医学新时代；2）构建首个健康人肝脏蛋白质组参比图谱及细胞分辨率的肝脏蛋白质组精细生理图谱，揭示肝脏构成细胞的分工原则及相互作用调控机制；3）探索肝脏蛋白质组的时空演变规律，揭示肝脏具有的胎肝造血及肝脏再生这两大独特能力的蛋白质组基础；4）鉴定非酒精性脂肪性肝病、乙型肝炎病毒感染、肝细胞癌变以及转移相关的始动因子及蛋白质标志物群。

Main research fields and directions: The main research direction is liver proteomics. The academic approach is to elucidate the physiological laws of the liver and determine key aspects of liver disease diagnosis and treatment by analyzing the proteomic composition and dynamic changes of the liver under different physiological and pathological states. Systematic analysis of the proteomes of healthy adult liver, fetal liver, and major liver diseases has been conducted. A series of original achievements have been made: 1) Constructed a multi-omics database of early hepatocellular carcinoma population cohorts, achieved the first proteomic molecular typing of early hepatocellular carcinoma and discovered new targets for precision therapy, opening a new era of proteomics-driven precision medicine; 2) Constructed the first reference map of healthy human liver proteome and a fine physiological map of liver proteome at cellular resolution, revealing the division of labor principles and interaction regulatory mechanisms of liver constituent cells; 3) Explored the spatiotemporal evolution patterns of liver proteome, revealing the proteomic basis of the liver’s two unique capabilities: fetal liver hematopoiesis and liver regeneration; 4) Identified initiating factors and protein biomarker groups related to non-alcoholic fatty liver disease, hepatitis B virus infection, hepatocellular carcinogenesis and metastasis.

1. Jiang Y#, Sun A#, Zhao Y#, Ying W#, Sun H#, Yang X#, Xing B#, Sun W, Ren L, Hu B, Li C, Zhang L, Qin G, Zhang M, Chen N, Zhang M, Huang Y, Zhou J, Zhao Y, Liu M, Zhu X, Qiu Y, Sun Y, Huang C, Yan M, Wang M, Liu W, Tian F, Xu H, Zhou J, Wu Z, Shi T, Zhu W, Qin J, Xie L, Fan J*, Qian X*, He F*. Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. Nature. 567, 257–61 (2019)
2. Fan X, et al, Jiang Y*. Repopulating Kupffer cells originate directly from hematopoietic stem cells. https://www.ncbi.nlm.nih.gov/pubmed/29116813 14, 351 (2023) doi: 10.1186/s13287-023-03569-0.