Xu Tan

The Xu Tan laboratory uses advanced high-throughput screening methods for virus-host interaction research and antiviral drug development. Research directions: 1. Genome-wide screening of key host factors for important pathogenic viruses and their structural-functional studies; 2. Screening and mechanism research of broad-spectrum antiviral drugs; 3. Systematic discovery of important viral cellular immune antigens and related vaccine development.

1. Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X. Gain-of-function genetic screening identifies antiviral function of TMEM120A via activating STING signaling. Nature Communications, 2022, 13: 105.
2. Liu Y*, Song Y*, Zhang S, Diao M, Huang S, Li S, Tan X. PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins. Cell Discovery, 2020, 6: 53.