Xiaoyun Liu

The research group focuses on biological mass spectrometry as the core, developing or applying novel proteomic analysis strategies to solve some important scientific problems in the field of pathogenic bacterial infections that have been pending for many years due to technical limitations. We have developed efficient and universal intracellular bacterial proteomics analysis strategies, providing novel perspectives for revealing the molecular mechanisms of pathogen adaptation to hosts. Meanwhile, we have established high-precision mass spectrometry analysis methods for novel protein modifications and deciphered a series of protein covalent modifications catalyzed by bacterial virulence factors, thereby elucidating new mechanisms of pathogen-host interactions. The research group has successively received support from the Overseas High-level Talent Introduction Program for Young Scholars and the National Science Fund for Excellent Young Scholars, and has published nearly 80 papers in journals such as Nature, Mol. Cell, PLOS Pathog., Mol. Cell. Proteomics, and J. Proteome Res.

1. Li Z, Liu W, Fu J, Cheng S, Xu Y, Wang Z, Liu X, Shi X, Liu Y, Qi X, Liu X*, Ding J, Shao F*. (2021) Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11. Nature, 599, 290-295.
2. Wang Z, Sun J, Xia T, Liu Y, Fu J, Lo YK, Chang C, Yan A*, Liu X*. (2018) Proteomic delineation of the ArcA regulon in Salmonella Typhimurium during anaerobiosis. Mol. Cell. Proteomics, 17, 1937-1947.