戴伦治 Lunzhi Dai

研究方向:1)开发微量蛋白质修饰组学新技术以突破了稀有细胞衰老研究中样品量少的限制;2)基于灵长类动物模型和临床队列发现肠道、肌肉、脑等器官衰老及相关疾病(肠癌、肌少症、类风湿关节炎等疾病)的风险因素,并研究相关的蛋白质修饰调控机制和干预靶点。

Research Interests: 1) Developing novel micro-scale protein modification omics technologies to overcome sample quantity limitations in rare cell aging research; 2) Based on primate models and clinical cohorts, discovering risk factors for aging and related diseases (colorectal cancer, sarcopenia, rheumatoid arthritis, etc.) in organs such as intestines, muscles, and brain, and studying related protein modification regulatory mechanisms and intervention targets.

Liu Y, Ge M, Xiao X, Lu Y, Zhao W, Zheng K, Yu K, He Y, Zhong Q, Zhou L, Hai S, Liu X, Jiang N, Du D, Zhang Y, Cheng G, An Z, Zhao Y, Xu H, Dong B, Li S, Ying B, Zhang H*, Yue J*, Dong B-R*, Dai L*. Sarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating anti-inflammatory macrophages. Nature Aging. 2025, in press.

Wang X, Luo Y, He S, Lu, Y, Gong Y, Gao L, Mao S, Liu X, Jiang N, Pu Q, Du D, Shu Y, Hai S, Li S, Chen H-N, Zhao Y, Xie D, Qi S, Lei P, Hu H, Xu H, Zhou Z-G, Dong B,* Zhang H,* Zhang Y,* Dai L*. Age, sex and proximal-distal resolved multi-omics identifies regulators of intestinal aging in non-human primates. Nature Aging. 2024;4(3):414-433.

Xiao X, Hu M, Gao L, Yuan H, Chong B, Liu Y, Zhang R, Gong Y, Du D, Zhang Y, Yang H, Liu X, Zhang Y, Zhang H, Xu H, Zhao Y, Meng W, Xie D, Lei P, Qi S, Peng Y, Tan T, Yu Y, Hu H, Dong B, Dai L*. Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut. Signal Transduction and Targeted Therapy. 2025;10(1):8.

Zhang R, Hu M, Liu Y, Li W, Xu Z, He S, Lu Y, Gong Y, Wang X, Hai S, Li S, Qi S, Li Y, Shu Y, Du D, Zhang H, Xu H, Zhou Z, Lei P*, Chen HN*, Dai L*. Integrative omics uncovers low tumorous magnesium content as a driver factor of colorectal cancer. Genomics Proteomics and Bioinformatics. 2024;22(4):qzae053.