Jun Qin

Professor Jun Qin is a nationally distinguished expert and Beijing distinguished expert. He is one of the few scholars in the world who integrates mass spectrometer design, proteomics method development, bioinformatics, biology, and clinical applications into the same research project. In protein complex research, he has established internationally leading protein complex purification and identification methods; in protein network research, he has established the world’s largest endogenous human protein complex dataset; has conducted extensive and fruitful research on DNA damage repair; successfully established the most efficient proteome scanning platform internationally; utilizing the characteristic that transcription factors can bind to their specific DNA sequences, designed and developed catTFRE to enrich endogenous transcription factors and transcriptional regulatory complexes in cells/tissues; led the development and construction of the world’s first one-stop proteomics data analysis cloud platform Firmiana; mapped the first proteomic landscape of diffuse gastric cancer and classified diffuse gastric cancer into three molecular subtypes closely related to survival prognosis and chemotherapy sensitivity; mapped the first anatomically resolved proteomic reference atlas of healthy human gastric mucosa and established quantitative reference ranges for the gastric mucosal proteome under physiological conditions; pioneered the establishment of quantitative reference ranges for human urine proteome covering intra-individual and inter-individual differences and physiological fluctuations, and conducted research on urinary proteins related to major diseases. He has led and participated in multiple national and provincial projects, including National International Science Cooperation Projects (Chief Investigator), 973 Program (Chief Investigator), National Key R&D Program, National Natural Science Foundation General Projects, and Beijing Science and Technology Commission projects. As corresponding author, he has published a series of articles in journals such as Cell, Nature Biotechnology, Nature Communications, Molecular Cell, Genes & Development, and PNAS. Total publications exceed 120 articles.

1. Zhan D, Zheng N, Zhao B, Cheng F, Tang Q, Liu X, Wang J, Wang Y, Liu H, Li X, Su J, Zhong X, Bu Q, Cheng Y, Wang Y, Qin J. Expanding individualized therapeutic options via genoproteomics. Cancer Lett. 2023 Apr 28;560:216123.
2. Li X, Zheng NR, Wang LH, Li ZW, Liu ZC, Fan H, Wang Y, Dai J, Ni XT, Wei X, Liu MW, Li K, Li ZX, Zhou T, Zhang Y, Zhang JY, Kadeerhan G, Huang S, Wu WH, Liu WD, Wu XZ, Zhang LF, Xu JM, Gerhard M, You WC, Pan KF, Li WQ, Qin J. Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer. EBioMedicine. 2021 Dec;74:103714.
3. Yu Z, Li X, Quan Y, Chen J, Liu J, Zheng N, Liu S, Wang Y, Liu W, Qiu C, Wang Y, Zheng R, Qin J. Itaconate alleviates diet-induced obesity via activation of brown adipocyte thermogenesis. Cell Rep. 2024 May 28;43(5):114142.