Jian Wang

Professor Jian Wang, PhD supervisor, currently a researcher at the Institute of Life Omics, Academy of Military Medical Sciences. Has long been engaged in protein interaction omics and disease molecular mechanism research, mapping the first human organ (liver) protein interaction network, laying the foundation for the discovery of liver disease development mechanisms, diagnostic markers, and therapeutic targets; systematically analyzed the interaction networks between pathogens such as SARS-CoV-2 and hand-foot-mouth disease virus with hosts, and revealed the molecular regulatory mechanisms of major diseases such as inflammation and tumors. Has published over 80 papers in international journals including Mol Syst Biol, Nat Commun, PNAS, EMBO J, Nucleic Acids Res, Cell Chem Biol, and has led projects including the National Key R&D Program, 863 Program, and National Natural Science Foundation, receiving multiple awards including the National Science and Technology Progress Innovation Team Award and Beijing Science and Technology Progress First Prize. Research Interest: Proteomics and disease molecular mechanisms.

Selected Publications:
1. Zhang Y, Shang L, Zhang J, …, Wang J#. An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Cell Chem Biol. 2022, 29(1):5-18.
2. Shang L, Zhang Y, Liu Y, …, Wang J#. A yeast BiFC-seq method for genome-wide interactome mapping. Genomics Proteomics Bioinformatics. 2022, 20(4):795-807.
3. Wei J, Yuan Y, Chen L, …, Wang J#, He F#. ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes. Nat Commun. 2018, 9(1):3659.
4. Wei J, Wei C, Wang M, …, Wang J#, Yang X#, He F#. The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling. PNAS. 2014, 111(24):8883-8.
5. Wang J*, Huo K*, Ma L*, …, He F#, Yang X#. Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011;7:536.