Hong Wang

Researcher, doctoral supervisor, and assistant professor in the tenure-track series at Peking Union Medical College. Completed PhD and postdoctoral training at St. Jude Children’s Research Hospital, USA. Has received titles including National High-level Young Top Talent, National High-level Overseas Talent, Tianjin Outstanding Youth Fund, and Leading Talent in Scientific and Technological Innovation. Currently serves as Deputy Director of the Science and Technology Department, Director of the Frontier Technology Center at Haihe Laboratory, and Co-Director of the Precision Medicine Laboratory. Serves as principal investigator for multiple national-level projects including NSFC special and general programs. Holds academic positions including member of the Asia-Pacific Human Proteome Organization and head of the Blood Protein Working Group of the Chinese Proteomics Society. Has published multiple high-level papers as corresponding/first author in Immunity (cover article), Cancer Cell, Nat Commun, PNAS, etc., with over 3000 total citations. Has applied for 2 national invention patents and 1 global PCT patent, with 1 authorized. Achievements have received recognition as one of the Top Ten Research Advances in Chinese Hematology and the “Proteomics Highlight of the Year” award selected by the Human Proteome Organization (one of three globally selected). Research Interests: Leukemia drug resistance; development and translation of cutting-edge multi-omics technologies; bioinformatics; aging.

Publications in the Last 5 Years:
Dandan Yang#, Tingting Zhang#, Yang Yang#, Dong Zhang, Zhiwei Zhou, Ning Wang, Jinting Fan, Chenghua Xu, Youyang Fang, Lichun Kang, Mingming Niu, Chunliang Li, Long Shen∗, Hong Wang∗. Integration of CRISPR-Cas9 screens and multi-omics profiling reveals chromodomain helicase DNA binding protein 7-angiopoietin-1 as a novel multidrug resistance axis in acute myeloid leukemia. Interdisciplinary Medicine. 2025. e70053 (封面故事)
Wenchang Qian#, Penglei Jiang#, Mingming Niu#, Yujuan Fu#, Deyu Huang, Dong Zhang, Ying Liang, Qiwei Wang, Yingli Han, Xin Zeng, Yixin Shi, Lingli Jiang, Zebin Yu, Jinxin Li, Huan Lu, Hong Wang∗, Baohui Chen∗, Pengxu Qian∗. Selective identification of epigenetic regulators at methylated genomic sites by SelectID. Nature Communications. 2025.16(1): 3709
Mingming Niu#, Ning Wang#, Dandan Yang#, Lixia Fu#, Yang Yang, Long Shen, Hong Wang∗, Xianfeng Shao∗. Multi-omics integration reveals immune hallmarks and biomarkers associated with FLT3 inhibitor sensitivity in FLT3-mutated AML. Blood Science.7(2):p e00227, June 2025.
Hong Wang∗, Tao Cheng∗. Towards a blood ecosystem approach to dissect systemic diseases. Sci China Life Sci. 2024. 67 (7), 1528-1531
Hong Wang∗#, Cuicui Liu#, Xiaowei Xie#, Mingming Niu#, Yingrui Wang#, Xuelian Cheng#, Biao Zhang#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma, Huijun Wang, Guoqing Zhu, Yang Lu, Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentiao Jiang, Ximo Wang∗, Zhongyang Shen∗, Tiannan Guo∗, Jiaxi Zhou∗, Ping Zhu∗, Tao Cheng∗. Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection. Immunity. 2023.56(6): 1410-1428 (封面故事)
Shaela Wright#, Jianzhong Hu#, Hong Wang#, Judith Hyle, Yang Zhang, Guoqing Du, Marina Y Konopleva, Steven M Kornblau, Mohamed Nadhir Djekidel, Wojciech Rosikiewicz, Beisi Xu, Rui Lu, Jun J Yang∗, Chunliang Li∗. Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens. Proc Natl Acad Sci USA. 2023. Apr 18;120(16):e2220134120
Beisi Xu#, Hong Wang#, Shaela Wright, Judith Hyle, Yang Zhang, Ying Shao, Mingming Niu, Yiping Fan, Wojciech Rosikiewicz, Mohamed Nadhir Djekidel, Junmin Peng, Rui Lu, Chunliang Li∗. Acute depletion of CTCF rewires genome-wide chromatin accessibility. Genome Biology. 2021.22 (1):1-25
Hong Wang∗#, Kaushik Kumar Dey#, Ping-Chung Chen, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Xusheng Wang, Bing Bai, Yun Jiao, Surendhar Reddy Chepyala, Vahram Haroutunian, Bin Zhang, Thomas G. Beach and Junmin Peng∗. Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease. Molecular Neurodegeneration. 2020.15(1):43 (引用：100+)