王洪 Hong Wang

研究员、博士生（后）导师、北京协和医学院准聘长聘系列助理教授。博士和博后完成于美国圣裘德儿童研究医院。获国家高层青年拔尖人才、国家高层次留学人才、天津市杰青、科技创新领军人才等称号。目前任院所科技处副处长、海河实验室前沿技术中心主任及精准医学实验室联席主任。担任国自然基金委专项和面上等多项国家级项目首席。兼任亚太人类蛋白质组协会委员、中国蛋白质组学会血液蛋白质工作组组长等学术职务。以通讯/一作在Immunity（封面文章）、Cancer Cell、Nat Commun、PNAS等发表高水平论文多篇，总被引次数3000+，申请国家发明专利2项、全球PCT专利1项，授权1项。成果获中国血液学十大研究进展、国际人类蛋白质组协会评选的年度亮点成果奖”Proteomics Highlight of the Year”（全球遴选三项）。研究方向：白血病耐药；前沿多组学技术开发和转化；生物信息学；衰老。

Researcher, doctoral supervisor, and assistant professor in the tenure-track series at Peking Union Medical College. Completed PhD and postdoctoral training at St. Jude Children’s Research Hospital, USA. Has received titles including National High-level Young Top Talent, National High-level Overseas Talent, Tianjin Outstanding Youth Fund, and Leading Talent in Scientific and Technological Innovation. Currently serves as Deputy Director of the Science and Technology Department, Director of the Frontier Technology Center at Haihe Laboratory, and Co-Director of the Precision Medicine Laboratory. Serves as principal investigator for multiple national-level projects including NSFC special and general programs. Holds academic positions including member of the Asia-Pacific Human Proteome Organization and head of the Blood Protein Working Group of the Chinese Proteomics Society. Has published multiple high-level papers as corresponding/first author in Immunity (cover article), Cancer Cell, Nat Commun, PNAS, etc., with over 3000 total citations. Has applied for 2 national invention patents and 1 global PCT patent, with 1 authorized. Achievements have received recognition as one of the Top Ten Research Advances in Chinese Hematology and the “Proteomics Highlight of the Year” award selected by the Human Proteome Organization (one of three globally selected). Research Interests: Leukemia drug resistance; development and translation of cutting-edge multi-omics technologies; bioinformatics; aging.

近5年发表论文：
Dandan Yang#, Tingting Zhang#, Yang Yang#, Dong Zhang, Zhiwei Zhou, Ning Wang, Jinting Fan, Chenghua Xu, Youyang Fang, Lichun Kang, Mingming Niu, Chunliang Li, Long Shen∗, Hong Wang∗. Integration of CRISPR-Cas9 screens and multi-omics profiling reveals chromodomain helicase DNA binding protein 7-angiopoietin-1 as a novel multidrug resistance axis in acute myeloid leukemia. Interdisciplinary Medicine. 2025. e70053 (封面故事)
Wenchang Qian#, Penglei Jiang#, Mingming Niu#, Yujuan Fu#, Deyu Huang, Dong Zhang, Ying Liang, Qiwei Wang, Yingli Han, Xin Zeng, Yixin Shi, Lingli Jiang, Zebin Yu, Jinxin Li, Huan Lu, Hong Wang∗, Baohui Chen∗, Pengxu Qian∗. Selective identification of epigenetic regulators at methylated genomic sites by SelectID. Nature Communications. 2025.16(1): 3709
Mingming Niu#, Ning Wang#, Dandan Yang#, Lixia Fu#, Yang Yang, Long Shen, Hong Wang∗, Xianfeng Shao∗. Multi-omics integration reveals immune hallmarks and biomarkers associated with FLT3 inhibitor sensitivity in FLT3-mutated AML. Blood Science.7(2):p e00227, June 2025.
Hong Wang∗, Tao Cheng∗. Towards a blood ecosystem approach to dissect systemic diseases. Sci China Life Sci. 2024. 67 (7), 1528-1531
Hong Wang∗#, Cuicui Liu#, Xiaowei Xie#, Mingming Niu#, Yingrui Wang#, Xuelian Cheng#, Biao Zhang#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma, Huijun Wang, Guoqing Zhu, Yang Lu, Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentiao Jiang, Ximo Wang∗, Zhongyang Shen∗, Tiannan Guo∗, Jiaxi Zhou∗, Ping Zhu∗, Tao Cheng∗. Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection. Immunity. 2023.56(6): 1410-1428 (封面故事)
Shaela Wright#, Jianzhong Hu#, Hong Wang#, Judith Hyle, Yang Zhang, Guoqing Du, Marina Y Konopleva, Steven M Kornblau, Mohamed Nadhir Djekidel, Wojciech Rosikiewicz, Beisi Xu, Rui Lu, Jun J Yang∗, Chunliang Li∗. Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens. Proc Natl Acad Sci USA. 2023. Apr 18;120(16):e2220134120
Beisi Xu#, Hong Wang#, Shaela Wright, Judith Hyle, Yang Zhang, Ying Shao, Mingming Niu, Yiping Fan, Wojciech Rosikiewicz, Mohamed Nadhir Djekidel, Junmin Peng, Rui Lu, Chunliang Li∗. Acute depletion of CTCF rewires genome-wide chromatin accessibility. Genome Biology. 2021.22 (1):1-25
Hong Wang∗#, Kaushik Kumar Dey#, Ping-Chung Chen, Yuxin Li, Mingming Niu, Ji-Hoon Cho, Xusheng Wang, Bing Bai, Yun Jiao, Surendhar Reddy Chepyala, Vahram Haroutunian, Bin Zhang, Thomas G. Beach and Junmin Peng∗. Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease. Molecular Neurodegeneration. 2020.15(1):43 (引用：100+)