陆豪杰 Haojie Lu

复旦大学化学系教授，复旦大学生物医学研究院研究员。研究方向：课题组研究兴趣是基于生物质谱的蛋白质组学新技术新方法建立与应用研究。与疾病相关的蛋白质往往是丰度较低的蛋白质并和蛋白质翻译后修饰有关，这些重要的蛋白质由于本身存在的量极少或修饰的量极少而很难得以有效鉴定。低丰度蛋白质和蛋白质翻译后修饰的精准质谱定性和定量分析作为一个艰巨的前沿研究任务，适合质谱鉴定的样品处理方法和相应的质谱分析方法对实现该任务起着首要和关键作用。课题组建立了一系列复杂背景干扰下低丰度蛋白质和翻译后修饰蛋白质的高灵敏鉴定和高准确定量新方法，在重大疾病蛋白质标志物高灵敏鉴定和高准确验证关键环节获系列重要成果。

Professor at the Department of Chemistry, Fudan University, and Researcher at the Institutes of Biomedical Sciences, Fudan University. Research interests: The research group focuses on establishing and applying new technologies and methods in proteomics based on biological mass spectrometry. Disease-related proteins are often low-abundance proteins associated with post-translational modifications. These important proteins are difficult to identify effectively due to their extremely low abundance or minimal modifications. Precise mass spectrometric qualitative and quantitative analysis of low-abundance proteins and post-translational modifications represents a challenging frontier research task, where sample preparation methods suitable for mass spectrometric identification and corresponding mass spectrometric analysis methods play primary and critical roles. The research group has established a series of new methods for highly sensitive identification and highly accurate quantification of low-abundance proteins and post-translationally modified proteins under complex background interference, achieving important results in the highly sensitive identification and highly accurate validation of protein biomarkers for major diseases.

1. Li Zhonghua*, Du Qi, Feng Xiaoxiao, Song Xuezheng, Ren Zhenggang, Lu Haojie*. A One-Step Enzymatic Strategy for Efficient Imaging and Mapping of Tumor-Associated Tn Antigen. J Am Chem Soc, 2024, 146, 30, 20539–20543.
2. Wang Ting, Ma Shiyun, Ji Guanghui, Wang Guoli, Liu Yang, Zhang Lei, Zhang Ying*, and Lu Haojie*. A Chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun, 2024, 15, 2997.