Feng Zhou

Research Directions:
1. Innovative Medical Devices
Principal Investigator Zhou Feng, in collaboration with the Eye & ENT Hospital of Fudan University, developed the original LipiFlow dry eye treatment technology. The developed LipiFlow dry eye treatment device won the 2023 Shanghai Class II Innovative Medical Device Award and has obtained product registration certificate and production license issued by NMPA. The LipiFlow dry eye treatment device won the second prize in the 2024 Shanghai Chunsheng Cup Medical Innovation Competition (second award winner).
2. Single-cell Functional Proteomics
Relying on an innovative high-sensitivity proteomics platform, high-throughput detection of cellular functional proteomes is performed, with multiple achievements published in top journals such as Cell, Nature Cell Biology, Nature Microbiology, Nature Communications, and Analytical Chemistry.
3. Deep High-coverage Antibody Reactome
Using a constructed antigen library to capture antigen-antibody complexes, combined with DEEP SEQ deep proteomics along with immunoprecipitation and magnetic bead enzymatic digestion strategies, bioinformatics analysis is used to discover potential autoantibodies that play important roles in autoimmune diseases, tumors and other diseases. This plays an important role in further understanding the occurrence and development of these diseases. Results have been published in the authoritative journal Annals of the Rheumatic Diseases.

Representative Publications:
1.Liang, M., Wang, L., Tian, X., Wang, K., Zhu, X., Huang, L., Li, Q., Ye, W., Chen, C., Yang, H., Wu, W., Chen, X., Zhu, X., Xue, Y., Wan, W., Wu, Y., Lu, L., Wang, J., Zou, H., Ying, T., & Zhou, F*. (2024). “Identification and validation of anti-protein arginine methyltransferase 5 (PRMT5) antibody as a novel biomarker for systemic sclerosis (SSc). Annals of the Rheumatic Diseases.” IF: 27.2 （* Corresponding author）