赵世民 Shimin Zhao

国家自然科学基金委”代谢生物化学”创新研究群体负责人
教育部长江学者奖励计划 特聘教授
科技部万人计划创新研究群体负责人
国家重大科学研究计划（973） 首席科学家
复旦大学代谢与整合生物研究院，教授，副院长
国家”生物治疗协同创新中心” 前沿平台主任
复旦大学附属妇产科医院教授，研究所所长
复旦大学生命科学学院 教授（双聘）
复旦大学生物医学研究院 高级PI（双聘）
中国、美国NSF、香港、新加坡、澳门等 基金项目 评委
2000年获美国Purdue大学博士，任职美国Procter&Gamble（宝洁）公司科学家。2006年全职回国任职复旦大学，从事营养代谢物失调与人类疾病关系基础研究。全职回国后的贡献包括：1，在国际上开创性的发现了代谢酶的乙酰化调控机制，开辟代谢调控研究新领域, 成果以专门章节编入国际通用本科教材（Biochemistry，主编Garrett & Grisham，2016年第6版）；2，在国际上率先提出代谢物参与细胞信号通路调控的概念，发现代谢酶突变致肿瘤机理，成果收入国际权威肿瘤生物学教科书（The Biology of Cancer，by R. Weinberg）；3，发现胞内氨基酸感知分子机制，揭示氨基酸失调的致病机制。
以复旦为第一作者或通讯作者发表SCI论文40多篇包括Science（3篇）、Cancer Cell、Cell Metabolism（2篇）、Molecular Cell（2篇）、Circulation、Nature Communications（4篇）等知名学术期刊。成果近20次被Science、Nature、Cell、Molecular Cell、Cancer Discovery及Nature China（5次）等期刊专文介绍或评述。获邀在哈佛大学、加州大学伯克利分校及众多国际会议讲学或报告。至少有5篇研究论文成为国际近年热点引用论文。回国后发表的论文总引用超过5500次。
“代谢酶的乙酰化调控机制的发现”等成果先后入选美国化学会”2010年超级成果”、科技部”中国科学十大进展”、教育部”中国高校十大科技进展”等,获”谈家祯生命科学创新奖”，”明治乳业生命科学杰出奖”，”药明康德学者奖”,上海市首届”校园新星-科研新星””上海市科委优秀学术带头人”及”上海市领军人才”等多项个人荣誉。
回国来主持包括科技部973、重点基础研究计划（首席，2项）、重大国际合作（1项）项目，基金委重点（4项）、重大专项重点支持项目（1项），上海市基础研究重点项目等多项国家及市部级科研项目，获各项研究基金总资助超过7000万元。

Head of the “Metabolic Biochemistry” Innovative Research Group of the National Natural Science Foundation of China
Distinguished Professor of the Ministry of Education Yangtze River Scholars Award Program
Head of the Ministry of Science and Technology Ten Thousand Talents Program Innovative Research Group
Chief Scientist of the National Major Scientific Research Program (973)
Professor and Vice Dean, Institute of Metabolism and Integrative Biology, Fudan University
Director of the Frontier Platform of the National “Collaborative Innovation Center for Biotherapy”
Professor and Director of the Research Institute, Obstetrics and Gynecology Hospital Affiliated to Fudan University
Professor, School of Life Sciences, Fudan University (joint appointment)
Senior PI, Institutes of Biomedical Sciences, Fudan University (joint appointment)
Reviewer for grant projects in China, US NSF, Hong Kong, Singapore, Macau, etc.
Received Ph.D. from Purdue University in 2000, and worked as a scientist at Procter & Gamble in the United States. He returned to China full-time in 2006 to join Fudan University, engaged in basic research on the relationship between nutritional metabolite disorders and human diseases. Contributions after returning to China full-time include: 1. Pioneering discovery of the acetylation regulatory mechanism of metabolic enzymes internationally, opening up a new field of metabolic regulation research, with results included in a special chapter of an internationally used undergraduate textbook (Biochemistry, edited by Garrett & Grisham, 6th edition in 2016); 2. First proposing the concept of metabolite participation in cell signaling pathway regulation internationally, discovering the mechanism by which metabolic enzyme mutations cause tumors, with results included in the authoritative international tumor biology textbook (The Biology of Cancer, by R. Weinberg); 3. Discovering the intracellular amino acid sensing molecular mechanism, revealing the pathogenic mechanism of amino acid disorders.
As first author or corresponding author from Fudan, he has published more than 40 SCI papers including Science (3 articles), Cancer Cell, Cell Metabolism (2 articles), Molecular Cell (2 articles), Circulation, Nature Communications (4 articles) and other well-known academic journals. The results have been featured or reviewed nearly 20 times in journals such as Science, Nature, Cell, Molecular Cell, Cancer Discovery and Nature China (5 times). He has been invited to lecture or report at Harvard University, University of California, Berkeley and numerous international conferences. At least 5 research papers have become hotly cited papers internationally in recent years. The total citations of papers published after returning to China exceed 5,500.
Achievements such as “Discovery of the Acetylation Regulatory Mechanism of Metabolic Enzymes” have been successively selected as the American Chemical Society’s “2010 Super Achievement,” the Ministry of Science and Technology’s “Top Ten Advances in Chinese Science,” the Ministry of Education’s “Top Ten Scientific and Technological Advances in Chinese Universities,” etc., and he has received the “Tan Jiazhen Life Science Innovation Award,” “Meiji Dairy Life Science Outstanding Award,” “WuXi AppTec Scholar Award,” Shanghai’s first “Campus Star – Research Star,” “Shanghai Science and Technology Commission Outstanding Academic Leader” and “Shanghai Leading Talent” and many other personal honors.
Since returning to China, he has led numerous national and municipal-level research projects including the Ministry of Science and Technology 973, Key Basic Research Program (Chief, 2 projects), Major International Cooperation (1 project) projects, Foundation Committee Key projects (4 projects), Major Special Key Support Projects (1 project), Shanghai Basic Research Key Projects, etc., receiving total research funding of over 70 million yuan.

近年项目相关代表研究论文（选自20余篇已发表论文，*通讯作者）

Recent Representative Research Papers Related to Projects (selected from more than 20 published papers, *corresponding author)

1.Ya-Nan Qiao et al.,….Shi-Min Zhao*. Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/ glutamate ratio to inhibit epilepsy. Cell Discovery (2024) （IF：33.5）

2.Kai-Hui Zhang et al.,….Cong-Jian Xu* , Yi-Yuan Yuan* , Shi-Min Zhao*. Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation. Protein & Cell (2024) （IF：21.2）

3.Yunzi Mao et al.,….Wei Xu*, Shimin Zhao*. Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation. Cell Research (2024)（IF：44.1）