李惠琳 Huilin Li

简介：李惠琳，博士，中山大学教授，博导。2017年12月通过”中山大学百人计划”进入中山大学药学院工作。长期从事生物质谱研究，围绕完整蛋白的直接测序及修饰位点定位、蛋白-药物作用机制及蛋白非共价复合物的结构解析等科学难题开发质谱新方法，以实现对蛋白复合物结构及药物作用机制的深度探索。其研究成果发表在Nature Chemistry, Analytical Chemistry, J. Am. Soc. Mass Spectrom.等国际主流化学、分析及质谱类杂志。

Introduction: Dr. Huilin Li, Professor and doctoral supervisor at Sun Yat-sen University. Joined the School of Pharmaceutical Sciences at Sun Yat-sen University in December 2017 through the “Sun Yat-sen University Hundred Talents Program”. Has long been engaged in biological mass spectrometry research, developing new mass spectrometry methods around scientific challenges such as direct sequencing of intact proteins and modification site localization, protein-drug interaction mechanisms, and structural analysis of protein non-covalent complexes, to achieve in-depth exploration of protein complex structures and drug action mechanisms. Research results have been published in international mainstream chemistry, analytical and mass spectrometry journals such as Nature Chemistry, Analytical Chemistry, and J. Am. Soc. Mass Spectrom.

研究方向：
（1）开发及利用整合结构质谱技术（包括native top-down MS, HDX-MS, cross-linking MS等）研究蛋白质机器（蛋白-药物、蛋白-蛋白、蛋白-DNA等）的结构和功能；
（2）开发middle-down/top-down蛋白质组学技术探索蛋白翻译后修饰（PTMs）在生命过程中的调控机制。

Research Directions:
(1) Develop and utilize integrated structural mass spectrometry technologies (including native top-down MS, HDX-MS, cross-linking MS, etc.) to study the structure and function of protein machinery (protein-drug, protein-protein, protein-DNA, etc.);
(2) Develop middle-down/top-down proteomics technologies to explore the regulatory mechanisms of protein post-translational modifications (PTMs) in life processes.

1. Y Luo, H Li*. Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs). Int. J. Mol. Sci. 2020, 21(22), 8828; https://doi.org/10.3390/ijms21228828