Shunxing Chen

Research Interests:
Focused on chemical biology, systems toxicology, and proteomics technologies. Utilizing chemical methods, biological platforms, and computational approaches to study how chemical molecules perturb and regulate intracellular molecular networks, revealing their roles in disease manifestation and drug response.

Main research areas include:
1. Network biology and systems chemical biology technology development;
2. Chemical molecule intervention in protein-protein interaction networks;
3. Systems toxicology and systems pharmacology research;
4. Computational proteomics and network reconstruction; 5) Application of high-precision mass spectrometry platforms in omics analysis.

Sun S, Zheng Z, Wang J, Li F, He A, Lai K, Zhang S, Lu JH, Tian R, Tan CSH#. (2023) Improved in situ characterization of protein complex dynamics at scale with thermal proximity co-aggregation. Nature Communnication. 2023 Nov 24;14(1):7697. doi: 10.1038/s41467-023-43526-2.

Ji H, Lu X, Zhao S, Wang Q, Liao B, Bauer LG, Huber KVM, Luo R, Tian R, Tan CSH#. (2023) Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions. Cell Chemical Biology. 2023 Nov 16;30(11):1478-1487.e7. doi: 10.1016/j.chembiol.2023.08.002.