Haojie Lu

Professor at the Department of Chemistry, Fudan University, and Researcher at the Institutes of Biomedical Sciences, Fudan University. Research interests: The research group focuses on establishing and applying new technologies and methods in proteomics based on biological mass spectrometry. Disease-related proteins are often low-abundance proteins associated with post-translational modifications. These important proteins are difficult to identify effectively due to their extremely low abundance or minimal modifications. Precise mass spectrometric qualitative and quantitative analysis of low-abundance proteins and post-translational modifications represents a challenging frontier research task, where sample preparation methods suitable for mass spectrometric identification and corresponding mass spectrometric analysis methods play primary and critical roles. The research group has established a series of new methods for highly sensitive identification and highly accurate quantification of low-abundance proteins and post-translationally modified proteins under complex background interference, achieving important results in the highly sensitive identification and highly accurate validation of protein biomarkers for major diseases.

1. Li Zhonghua*, Du Qi, Feng Xiaoxiao, Song Xuezheng, Ren Zhenggang, Lu Haojie*. A One-Step Enzymatic Strategy for Efficient Imaging and Mapping of Tumor-Associated Tn Antigen. J Am Chem Soc, 2024, 146, 30, 20539–20543.
2. Wang Ting, Ma Shiyun, Ji Guanghui, Wang Guoli, Liu Yang, Zhang Lei, Zhang Ying*, and Lu Haojie*. A Chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun, 2024, 15, 2997.