戴伦治 Lunzhi Dai

Research Interests:
1. Developing novel micro-scale protein modification omics technologies to overcome sample quantity limitations in rare cell aging research;
2. Based on primate models and clinical cohorts, discovering risk factors for aging and related diseases (colorectal cancer, sarcopenia, rheumatoid arthritis, etc.) in organs such as intestines, muscles, and brain, and studying related protein modification regulatory mechanisms and intervention targets.

1. Liu Y, Ge M, Xiao X, Lu Y, Zhao W, Zheng K, Yu K, He Y, Zhong Q, Zhou L, Hai S, Liu X, Jiang N, Du D, Zhang Y, Cheng G, An Z, Zhao Y, Xu H, Dong B, Li S, Ying B, Zhang H*, Yue J*, Dong B-R*, Dai L*. Sarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating anti-inflammatory macrophages. Nature Aging. 2025, in press.

2. Wang X, Luo Y, He S, Lu, Y, Gong Y, Gao L, Mao S, Liu X, Jiang N, Pu Q, Du D, Shu Y, Hai S, Li S, Chen H-N, Zhao Y, Xie D, Qi S, Lei P, Hu H, Xu H, Zhou Z-G, Dong B,* Zhang H,* Zhang Y,* Dai L*. Age, sex and proximal-distal resolved multi-omics identifies regulators of intestinal aging in non-human primates. Nature Aging. 2024;4(3):414-433.

3. Xiao X, Hu M, Gao L, Yuan H, Chong B, Liu Y, Zhang R, Gong Y, Du D, Zhang Y, Yang H, Liu X, Zhang Y, Zhang H, Xu H, Zhao Y, Meng W, Xie D, Lei P, Qi S, Peng Y, Tan T, Yu Y, Hu H, Dong B, Dai L*. Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut. Signal Transduction and Targeted Therapy. 2025;10(1):8.

4. Zhang R, Hu M, Liu Y, Li W, Xu Z, He S, Lu Y, Gong Y, Wang X, Hai S, Li S, Qi S, Li Y, Shu Y, Du D, Zhang H, Xu H, Zhou Z, Lei P*, Chen HN*, Dai L*. Integrative omics uncovers low tumorous magnesium content as a driver factor of colorectal cancer. Genomics Proteomics and Bioinformatics. 2024;22(4):qzae053.