Introduction
Deep Visual Proteomics (DVP) is a cutting-edge spatial proteomics technology developed by Mann’s groups in Copenhagen and Munich. It integrates high-resolution microscopy, AI-powered cell segmentation, laser microdissection (LMD), and high-sensitivity mass spectrometry. This approach enables in-depth proteomic profiling at single-cell and subcellular resolution (>5000 proteins), applicable to both FFPE and fresh frozen tissue sections, and closely linked with morphological pathology.
Since its first publication in 2022, DVP has been successfully applied to a broad spectrum of diseases, demonstrating its unique ability to reveal cell-type resolved molecular mechanisms, for example, toxic epidermal necrolysis, a lethal skin disease, alpha-1 antitrypsin deficiency liver disease, as well as studies in types of cancers. These cases showcase DVP’s versatility in characterizing tissue heterogeneity, immune microenvironment, and disease progression, providing valuable insights for precision medicine.
This workshop will cover the complete DVP workflow – from sample preparation to data analysis – and present real-world case studies demonstrating its applications in oncology and translational medicine. The program runs from 09:00 to 13:30, with a working lunch and Q&A.
