Wenshu Meng

Dr. Meng earned her Ph.D. in Proteomics from Beijing Normal University from September 2017 to September 2022, under the supervision of Professor Youhe Gao. Since December 2022, she has been a Lecturer at Shandong University of Technology. Dr. Meng is a member of the Chinese Society of Biochemistry and Molecular Biology. Dr. Meng has long been engaged in applying proteomics to biomarker discovery and pathogenesis research in major diseases, focusing on autism spectrum disorder and other conditions. Using clinical urine samples and animal models, she employs DIA, PRM, and other proteomic techniques to systematically screen disease-associated differential proteins, construct non-invasive diagnostic biomarker candidate panels, and integrate bioinformatics analysis to explore underlying molecular mechanisms. Her research emphasizes the use of urine—a non-invasive, sensitive, and dynamically monitorable biofluid—to uncover early pathophysiological changes in diseases. A distinctive feature of her work is the combination of clinical cohorts with animal models for biomarker screening, pathway dissection, and mechanistic validation, offering both translational potential and fundamental research depth. These studies contribute to advancing early diagnosis, precise subtyping, and mechanistic understanding of diseases, providing new theoretical foundations and candidate targets for early screening, warning, and intervention in related disorders. Her related findings have been published in journals including Coordination Chemistry Reviews, Translational Pediatrics, Food Chemistry, International Journal of Molecular Sciences, and Clinica Chimica Acta.

Selected publications:
1. Meng W, Chen R, Jiang Q, Ma K, Li D, Xiao H, Chi W, Zeng C, Shu W. Recent mitochondria-immobilized fluorescent probes for high-fidelity bioimaging: From design to application. Coordination Chemistry Reviews, 2025, 529: 216456.
2. Meng W, Huan Y, Gao Y. Urinary proteome profiling for children with autism using data-independent acquisition proteomics. Translational Pediatrics, 2021, 10(7): 1765-1778.
3. Zhang P, Meng W, Wei L, Li Y, Xiao H, He Y, Yang F, Han X, Shu W. Rational design of a NIR fluorescent probe and its application in food detection of viscosity and biosystem imaging. Food Chemistry, 2024, 460(Pt3): 140527.
4. Meng W, Gao Y. Urinary Proteome Characterization of Stroke-Prone Spontaneously Hypertensive Rats. International Journal of Molecular Sciences, 2024, 26(1): 1-13.
5. Liu A, Sun L, Meng W. Proteomics of neuropsychiatric disorders. Clinica Chimica Acta, 2025, 567: 120093.