Jialin Liu

Dr. Liu earned her Ph.D. in Chemical Biology from Fudan University from September 2016 to November 2021. She conducted postdoctoral research and served as an Assistant Research Fellow at Peking University from December 2021 to November 2023. Since December 2023, she has been a Principal Investigator and Associate Research Fellow at the National Center for Protein Sciences (Beijing). Dr. Liu has long been engaged in interdisciplinary research at the intersection of mass spectrometry-based omics and glycochemical biology, focusing on the development of novel quantitative glycoproteomic technologies driven by chemical labeling, with an emphasis on dynamic profiling and functional studies of protein glycosylation. To address the challenges posed by the structural complexity, dynamic variability, and analytical difficulties in characterizing and quantifying multiple types of glycosylation, she introduced chemical labeling into glycoproteomics and established analytical workflows including IsoTPCL and Click-iG, enabling dynamic tracking of glycosylation events in specific biological processes. She has progressively built a technical system enabling high-coverage identification and precise quantification of multiple glycosylation types, including N-linked, O-GalNAc, and O-GlcNAc. Building on these methods, her research further focuses on biological processes such as stem cell differentiation, inflammation, and tumorigenesis, aiming to elucidate the dynamic changes and functional roles of glycosylation in cell fate determination and disease progression, and to explore the regulatory mechanisms of glycosylation information in complex biological systems. Her related findings have been published in journals including ACS Central Science, Nature Communications, Angewandte Chemie International Edition, and ACS Chemical Biology.

Selected publications:
1. Meng X#, Zhou Y#, Xu L, Hu L, Wang C, Tian X, Zhang X, Hao Y, Cheng B, Ma J, Wang L, Liu J, Xie R. O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression. ACS Cent Sci, 2024, 10: 1065-1083.
2. Liang S#, Guo H#, Xu Z#, Liu Z#, Liu X, Wei Z, Hou J, Yang W, Huang W, Wang W, Li J, Qian H, Ma W, Deng Z, Wang Y, Liu J, Rao Z, Wei W, Lou Z*. A dual-receptor checkpoint primes enterovirus D68 for respiratory cell entry. Nat Commun, accepted.
3. Liu J, Cheng B, Fan X, Zhou X, Wang J, Zhou W, Li H, Zeng W, Yang P, Chen X*. Click-iG: Simultaneous Enrichment and Profiling of Intact N-linked, O-GalNAc, and O-GlcNAcylated Glycopeptides. Angew Chem Int Ed, 2023, 62: e202303410.
4. Liu J#, Hao Y#, He Y, Li X, Sun DE, Zhang Y, Yang PY, Chen X. Quantitative and Site-Specific Chemoproteomic Profiling of Protein O-GlcNAcylation in the Cell Cycle. ACS Chem Biol, 2021, 16: 1917-1923.
5. Liu J#, Hao Y#, Wang C#, Jin Y, Yang Y, Gu J, Chen X*. An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis. ACS Chem Biol, 2022, 17: 513-520.