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\n\u5a04\u535a\u58eb\u7684\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u5305\u62ec\uff1a
\n\uff081\uff09\u6784\u5efa\u86cb\u767d\u8d28\u7ec4\u5b66\u9a71\u52a8\u7684\u764c\u75c7\u8bca\u7597\u65b0\u6a21\u5f0f\u2014\u2014\u5229\u7528DIA-MS\u3001HuProt\u2122\u53ca\u6297\u4f53\u82af\u7247\u6280\u672f\uff0c\u9996\u6b21\u63cf\u7ed8\u4e86\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u8840\u6d46\u86cb\u767d\u8d28\u7ec4\u5168\u666f\uff0c\u63d0\u51faPS-I-IV\u56db\u79cd\u5206\u5b50\u5206\u578b\uff0c\u8bc6\u522b\u51fa\u5173\u952e\u86cb\u767dTIMP-1\uff0c\u76f8\u8f83\u4e8e\u4f20\u7edf\u6807\u5fd7\u7269\u53ef\u5c06\u590d\u53d1\u98ce\u9669\u8bc6\u522b\u7387\u63d0\u534720%-40%\uff08Molecular & Cellular Proteomics, 2023\uff09\uff1b\u6b64\u5916\uff0c\u9274\u5b9a\u4e86\u6297IFIT5\u3001\u6297PAH\u7b49\u56db\u79cd\u8840\u6e05\u81ea\u8eab\u6297\u4f53\u6807\u5fd7\u7269\uff0c\u663e\u8457\u4f18\u5316\u4e86\u524d\u5217\u817a\u764c\u65e9\u671f\u5c24\u5176\u662f\u201cPSA\u7070\u533a\u201d\u60a3\u8005\u7684\u65e9\u671f\u8bca\u65ad\u6548\u80fd\uff08CIL, 2023\uff09\uff1b
\n\uff082\uff09\u57fa\u4e8e\u591a\u7ec4\u5b66\u9274\u5b9a\u9884\u540e\u6807\u5fd7\u7269\uff0c\u6316\u6398\u8010\u836f\u673a\u5236\uff0c\u63d0\u51fa\u6cbb\u7597\u65b0\u7b56\u7565\u2014\u2014\u8054\u5408\u7a7a\u95f4\u7ec4\u5b66\u4e0e\u86cb\u767d\u8d28\u7ec4\u5b66\u9a8c\u8bc1\uff0c\u63ed\u793a\u4e86FAS\u3001LYZ\u3001LILRB4\u7b49\u86cb\u767d\u5728\u6dcb\u5df4\u7624\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u7684\u9884\u540e\u4ef7\u503c\uff08Sci China Life Sci, 2025\uff1bCIL, 2025\uff09\uff1b\u9488\u5bf9\u80ba\u764c\u4e09\u4ee3EGFR-TKI\u7684\u8010\u836f\u96be\u9898\uff0c\u53d1\u73b0\u6eb6\u8840\u78f7\u8102\u4ee3\u8c22\u7d0a\u4e71\u53ef\u4ecb\u5bfc\u8010\u836f\u7684\u53d1\u751f\uff0c\u6eb6\u8840\u78f7\u8102\u4ee3\u8c22\u9176\u53ef\u4f5c\u4e3a\u9884\u540e\u9884\u6d4b\u6807\u5fd7\u7269\uff08Clin Cancer Res, 2025\uff09\uff1b
\n\uff083\uff09\u7b97\u6cd5\u8d4b\u80fd\u4e34\u5e8a\u51b3\u7b56\u652f\u6301\u2014\u2014\u63d0\u51faCoxMoE\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\uff0c\u6574\u5408\u8840\u6d46\u86cb\u767d\u6c34\u5e73\u3001\u4e34\u5e8a\u75c5\u5386\u4e0e\u836f\u4ee3\u52a8\u529b\u5b66\u591a\u7ef4\u6570\u636e\uff0c\u5b9e\u73b0\u4e86\u5bf9\u80ba\u764c\u9776\u5411\u6cbb\u7597\u54cd\u5e94\u4e0e\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7684\u7cbe\u51c6\u9884\u6d4b\uff08TLCR, 2024\uff1bComm Med, under review\uff09\u3002<\/p>\n
<\/p>\n
\u4ee3\u8868\u4f5c\uff1a
\n1. Lou N, Wang G, Wang Y, Xu M, Zhou Y, Tan Q, Zhong Q, Zhang L, Zhang X, Liu S, Luo R, Wang S, Tang L, Yao J, Zhang Z, Shi Y, Yu X, Han X. Proteomics Identifies Circulating TIMP-1 as a Prognostic Biomarker for Diffuse Large B-Cell Lymphoma. Mol Cell Proteomics, 2023, 22(9): 100625.
\n2. Lou N, Yang M, Xie Z, Gao R, Zhang L, Tang L, Yao J, Han X, Shi Y. JAK3A573V and JAK3M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3\/PD-L1 pathway. J Immunother Cancer, 2025, 13(4).
\n3. Gao R, Lou N, Yang S, Yang M, Fan G, Dai L, Tang L, Yao J, Han X, Shi Y. Multiomics and Single-Cell Insights Reveal a Lysophosphatidic Acid-Mediated Resistant Mechanism to Third-generation EGFR-TKI in Non-Small Cell Lung Cancer. Clin Cancer Res, 2025, 31(22): 4814-4831.
\n4. Lou N, Dai L, Gao R, Yang J, Gui L, Yang S, Liu P, Shi Y, Han X. Single-cell sequencing and spatial transcriptomics reveal FAS+ T cell and autophagy-related signatures predicting chemoimmunotherapy response in diffuse large B-cell lymphoma patients. Sci China Life Sci, 2025 May 15.
\n5. Lou N, Zheng C, Wang Y, Liang C, Tan Q, Luo R, Zhang L, Xie T, Shi Y, Han X. Identification of novel serological autoantibodies in Chinese prostate cancer patients using high-throughput protein arrays. Cancer Immunol Immunother, 2023, 72(1): 235-247.<\/p>","protected":false},"featured_media":1404,"template":"","member_cat":[],"class_list":["post-1424","member","type-member","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member\/1424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member"}],"about":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/types\/member"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/media\/1404"}],"wp:attachment":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/media?parent=1424"}],"wp:term":[{"taxonomy":"member_cat","embeddable":true,"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member_cat?post=1424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}