{"id":1394,"date":"2026-06-17T14:20:52","date_gmt":"2026-06-17T06:20:52","guid":{"rendered":"http:\/\/cnhupo.org.cn\/?post_type=member&#038;p=1394"},"modified":"2026-06-17T14:20:52","modified_gmt":"2026-06-17T06:20:52","slug":"yuanxiang-lao","status":"publish","type":"member","link":"http:\/\/cnhupo.org.cn\/zh\/member\/yuanxiang-lao\/","title":{"rendered":"\u52b3\u8fdc\u7fd4"},"content":{"rendered":"<p>\u52b3\u535a\u58eb\u4e8e2012\u5e749\u6708\u81f32016\u5e746\u6708\u5728\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u653b\u8bfb\u9057\u4f20\u5b66\u4e13\u4e1a\uff0c\u83b7\u7406\u5b66\u535a\u58eb\u5b66\u4f4d\uff1b2019\u5e749\u6708\u81f32023\u5e748\u6708\u5728\u5357\u4eac\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u9f13\u697c\u533b\u9662\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\uff1b2023\u5e749\u6708\u81f32025\u5e748\u6708\u5728\u5b89\u5fbd\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u4efb\u52a9\u7406\u7814\u7a76\u5458\uff1b2025\u5e7412\u6708\u8d77\u5728\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u90b5\u9038\u592b\u533b\u9662\u4efb\u7279\u8058\u7814\u7a76\u5458\u3002\u52b3\u535a\u58eb\u5728\u86cb\u767d\u8d28\u7ec4\u5b66\u4e0e\u7ffb\u8bd1\u540e\u4fee\u9970\u9886\u57df\u5f00\u5c55\u4e86\u7cfb\u7edf\u6027\u7814\u7a76\u5de5\u4f5c\uff1a\u9996\u6b21\u91c7\u75284D label-free\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\u89c2\u5bdf\u5df4\u8c46\u9170\u5316\u4fee\u9970\u524d\u540e\u4e0b\u6e38\u5019\u9009\u9776\u70b9\u7684\u8868\u8fbe\uff0c\u786e\u7acb\u4e86\u5176\u5728\u9176\u6d3b\u8c03\u63a7\u4e0a\u7684\u6291\u5236\u4f5c\u7528\uff0c\u53d1\u73b0GCDH\u53ef\u901a\u8fc7\u8870\u8001\u76f8\u5173\u7684\u5206\u6ccc\u8868\u578b\uff08SASP\uff09\u91cd\u5851\u4ee5NK\u7ec6\u80de\u4e3a\u4e3b\u3001M1\u578b\u5de8\u566c\u7ec6\u80de\u548c\u6d3b\u5316CD8+T\u7ec6\u80de\u4e3a\u8f85\u7684\u6297\u80bf\u7624\u5fae\u73af\u5883\uff0c\u800c\u5176\u4e0b\u8c03\u53c8\u53ef\u63d0\u5347PD-1+CD8+T\u7ec6\u80de\u7684\u6bd4\u4f8b\uff08Journal of Hepatology, 2024\uff09\uff1b\u7ed8\u5236\u4e86\u809d\u764c9\u79cd\u4e3b\u8981\u86cb\u767d\u8d28\u7ffb\u8bd1\u540e\u4fee\u9970\u7ec4\u8c31\u56fe\uff0c\u63ed\u793a\u809d\u764c\u86cb\u767d\u8d28\u7ffb\u8bd1\u540e\u4fee\u9970\u8c03\u63a7\u89c4\u5f8b\uff0c\u7814\u7a76\u53d1\u73b0\u5927\u591a\u6570\u78f7\u9178\u5316\u4f4d\u70b9\u4f4d\u4e8e\u56fa\u6709\u65e0\u5e8f\u533a\u57df\uff08IDR\uff09\u4e2d\uff0c\u5177\u6709\u9ad8\u7279\u5f02\u6027\u548c\u4f4e\u4eb2\u548c\u529b\uff0c\u800c\u5927\u591a\u6570\u9170\u5316\u4f4d\u70b9\u4f4d\u4e8e\u6298\u53e0\u533a\u57df\uff0c\u8868\u660ePTM\u5728HCC\u4e2d\u7684\u5206\u5e03\u5177\u6709\u7279\u5f02\u6027\uff0c\u4e14\u4e0e\u86cb\u767d\u8d28\u7684\u4e8c\u7ea7\u7ed3\u6784\u5bc6\u5207\u76f8\u5173\uff0c\u9178\u5316\u548c\u591a\u4e2a\u9170\u5316\u4fee\u9970\u4f4d\u70b9\u5728\u542b\u6709RNA\u8bc6\u522b\u57fa\u5e8f1\uff08RRM1\uff09\u7ed3\u6784\u57df\u7684\u86cb\u767d\u8d28\u4e2d\u5bcc\u96c6\uff0c\u4e14RNA\u526a\u63a5\u662f\u8be5\u86cb\u767d\u8d28\u5b50\u96c6\u7684\u5173\u952e\u7279\u5f81\uff08Molecular Cancer, 2024\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4ee3\u8868\u4f5c\uff1a<br \/>\n1. Lao, Yuanxiang#; Jin, Yirong#; Wu, Songfeng; Fang#, Ting; Wang, Qiang; Sun, Longqin; Sun, Beicheng; Deciphering a profiling based on multiple post-translational modifications functionally associated regulatory patterns and therapeutic opportunities in human hepatocellular carcinoma, Molecular Cancer, 2024, 23 (1): 283.<br \/>\n2. Yuanxiang Lao#; Xiaohan Cui#; Zhu Xu#; Hongyao Yan;# Zechuan Zhang; Zhenwei Zhang; Longpo Geng; Binghua Li; Yijun Lu; Qifei Guan; Xiaohong Pu; Suwen Zhao; Jiapeng Zhu; Xihu Qin; Beicheng Sun; Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma, Journal of Hepatology, 2024, 81 (5): 847-861.<br \/>\n3. 3. Xiaohan Cui; Xiao Yun; Meiling Sun; Renzhi Li; Xiajie Lyu; Yuanxiang Lao*; Wenbin Yu*; Xihu Qin*; HMGCL-induced \u03b2-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility, Hepatology International, 2023 (17): 377-392.<br \/>\n4. Yuanxiang Lao#; Yanyan Li#; Wei Wang; Liangliang Ren; Xiaohong Qian; Fuchu He*; Xinguo Chen*; Ying Jiang*; A Cytological Atlas of the Human Liver Proteome from PROTEOMESKY- LIVERHu 2.0, a Publicly Available Database, Journal of Proteome Research, 2022, 21 (8): 1916-1929.<br \/>\n5. Yuanxiang Lao, Yanyan Li, Ping Zhang, Qianqian Shao, Weiran Lin, Bintao Qiu, Yongzhuang Lv et al. Targeting endothelial Erk1\/2-Akt axis as a regeneration strategy to bypass fibrosis during chronic liver injury in mice. 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