\u4ed8\u535a\u58eb\u4e8e2018\u5e749\u6708\u81f32023\u5e746\u6708\u5728\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u4e34\u5e8a\u86cb\u767d\u8d28\u7ec4\u5b66\u4e0e\u7ed3\u6784\u751f\u7269\u5b66\u4e13\u4e1a\u653b\u8bfb\u535a\u58eb\u5b66\u4f4d\uff1b2025\u5e749\u6708\u8d77\u5728\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u536b\u5065\u59d4\u80bf\u7624\u86cb\u767d\u8d28\u7ec4\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4efb\u526f\u6559\u6388\u30022021\u5e7412\u6708\u81f3\u4eca\u62c5\u4efbFrontiers in Molecular Medicine\u671f\u520a\u7f16\u59d4\u3002\u4ed8\u535a\u58eb\u957f\u671f\u81f4\u529b\u4e8e\u80bf\u7624\u86cb\u767d\u8d28\u7ec4\u5b66\u7814\u7a76\uff0c\u805a\u7126\u4e8e\u80bf\u7624\u86cb\u767d\u8d28\u7ec4\u5168\u666f\u7ed8\u5236\u53ca\u5c0f\u5206\u5b50\u836f\u7269\u9776\u70b9\u53d1\u73b0\u3002\u4f5c\u4e3a\u9aa8\u5e72\u53c2\u4e0e\u56fd\u5bb6973A\u9879\u76ee\u5b50\u8bfe\u9898\uff0c\u9996\u6b21\u7cfb\u7edf\u63cf\u7ed8\u4e86\u4eba\u7c7b\u9f3b\u54bd\u764c\u86cb\u767d\u8d28\u7ec4\u8868\u8fbe\u8c31\uff0c\u7cfb\u7edf\u63ed\u793a\u4e86\u9f3b\u54bd\u764c\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u7279\u5f81\u53ca\u5176\u6f5c\u5728\u7684\u5206\u5b50\u673a\u5236\u548c\u6cbb\u7597\u9776\u70b9\u3002\u5728\u5316\u5b66\u86cb\u767d\u8d28\u7ec4\u5b66\u65b9\u5411\uff0c\u4ee5\u5171\u4ef7FGFR\u6291\u5236\u5242\u4e3a\u6a21\u578b\uff0c\u6574\u5408\u591a\u7ec4\u5b66\u65b9\u6cd5\u7cfb\u7edf\u89e3\u6790\u5176\u5728\u809d\u764c\u4e2d\u7684\u4f5c\u7528\u9776\u70b9\u7f51\u7edc\uff0c\u53d1\u73b0\u4e86\u5168\u65b0\u7684\u836f\u7269\u9776\u70b9\u5e76\u9610\u660e\u5176\u4f5c\u7528\u673a\u5236\u3002\u76f8\u5173\u6210\u679c\u4ee5\u7b2c\u4e00\/\u901a\u8baf\u4f5c\u8005\u5728Advanced Science\u3001Cell Death & Disease\u3001Journal of Medicinal Chemistry\u3001Molecular & Cellular Proteomics\u7b49\u9886\u57df\u91cd\u8981\u671f\u520a\u53d1\u8868SCI\u8bba\u658712\u7bc7\uff08JCR 1\u533a10\u7bc7\uff09\uff0c\u6388\u6743\u56fd\u5bb6\u53d1\u660e\u4e13\u52291\u9879\uff0c\u53c2\u7f16\u4e13\u84572\u90e8\uff0c\u4e3b\u6301\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u9752\u5e74\u9879\u76ee\u53ca\u6e56\u5357\u7701\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u54041\u9879\u3002<\/p>\n
<\/p>\n
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\n1. Ying Fu, Dandan Zhu , Xiaojuan Chen, Lingzhi Qu, Ming Guo, Shuhong Zhang, Guangyu Xu, Zhuchu Chen, Maoyu Li*, Yongheng Chen*. Integrative Multi-Omics Approaches Reveal Selectivity Profiles and Molecular Mechanisms of FIIN-2, a Covalent FGFR Inhibitor. Adv Sci (Weinh). 2025;12(14):e2412578.
\n2. Dandan Zhu, Zijian Zheng, Huixin Huang, Xiaojuan Chen, Shuhong Zhang, Zhuchu Chen, Ting Liu, Guangyu Xu*, Ying Fu*, Yongheng Chen*. Design, synthesis and biological evaluation of the activity-based probes for FGFR covalent inhibitor. Eur J Med Chem. 2025 May 22;295:117795. \uff08\u5171\u540c\u901a\u8baf\uff09
\n3. Ying Fu, Xujun Liang, Xinming Yang, Jianping Liu, Huichao Huang, Pengfei Zhang, Shisheng Li, Dandan Zhu, Ye Zhang, Fang Peng, Yongheng Chen*, Zhuchu Chen*. Proteomics profiling reveals the molecular signatures and potential therapeutic targets of human nasopharyngeal carcinoma. Mol Cell Proteomics (2023) 22(6) 100567
\n4. Jingzhi Li, Ming Guo, Lin Chen, Zhuchu Chen, Ying Fu*, Yongheng Chen*. Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma. Cell Death Dis. 2024;15(1):35. \uff08\u5171\u540c\u901a\u8baf\uff09
\n5. Yalan Deng, Liqing Lu, Xujun Liang, Jingzhi Li, Dandan Zhu, Huichao Huang, Ye Zhang, Xiangqian Zhang, Yongheng Chen, Xiaojin Liu*, Ying Fu*. DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway. Life Sci. 2023;312:121266. \uff08\u5171\u540c\u901a\u8baf\uff09<\/p>","protected":false},"featured_media":1368,"template":"","member_cat":[],"class_list":["post-1389","member","type-member","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member\/1389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member"}],"about":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/types\/member"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/media\/1368"}],"wp:attachment":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/media?parent=1389"}],"wp:term":[{"taxonomy":"member_cat","embeddable":true,"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member_cat?post=1389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}