{"id":1386,"date":"2026-06-16T15:33:12","date_gmt":"2026-06-16T07:33:12","guid":{"rendered":"http:\/\/cnhupo.org.cn\/?post_type=member&#038;p=1386"},"modified":"2026-06-16T15:49:30","modified_gmt":"2026-06-16T07:49:30","slug":"zhiya-fan","status":"publish","type":"member","link":"http:\/\/cnhupo.org.cn\/zh\/member\/zhiya-fan\/","title":{"rendered":"\u6a0a\u667a\u96c5"},"content":{"rendered":"<p>\u6a0a\u535a\u58eb\u4e8e2019\u5e749\u6708\u81f32025\u5e746\u6708\u5728\u519b\u4e8b\u79d1\u5b66\u9662\u836f\u7269\u5206\u6790\u5b66\u4e13\u4e1a\u653b\u8bfb\u535a\u58eb\u5b66\u4f4d\uff0c\u83b7\u7406\u5b66\u535a\u58eb\u5b66\u4f4d\uff1b2025\u5e7412\u6708\u8d77\u5728\u519b\u4e8b\u79d1\u5b66\u9662\u519b\u4e8b\u533b\u5b66\u7814\u7a76\u9662\u4efb\u52a9\u7406\u7814\u7a76\u5458\u3002\u6a0a\u535a\u58eb\u4e3b\u8981\u4ece\u4e8b\u65b0\u578b\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\u7814\u53d1\uff0c\u805a\u7126\u4f4e\u4e30\u5ea6\u529f\u80fd\u86cb\u767d\u53ca\u5176\u7ffb\u8bd1\u540e\u4fee\u9970\u7684\u7cbe\u51c6\u89e3\u6790\uff0c\u7cfb\u7edf\u6784\u5efa\u4e86\u4ece\u9ad8\u901a\u91cf\u6574\u4f53\u5206\u6790\u5230\u5355\u7ec6\u80de\u4e0e\u7a7a\u95f4\u5c3a\u5ea6\u89e3\u6790\u7684\u9ad8\u7075\u654f\u3001\u8d85\u5feb\u901f\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\u4f53\u7cfb\u3002\u6784\u5efa\u4e86O-GlcNAc\u7cd6\u57fa\u5316\u4e0e\u78f7\u9178\u5316\u8054\u5408\u5bcc\u96c6\u9274\u5b9a\u65b9\u6cd5\uff0c\u5b9e\u73b0\u5173\u952e\u4fee\u9970\u4fe1\u606f\u534f\u540c\u89e3\u6790\uff08Analyst, 2021\uff09\uff1b\u5f00\u53d1\u4e86\u8d85\u5feb\u901f\u6837\u672c\u5904\u7406\u4e0e\u9176\u53cd\u5e94\u4f53\u7cfb\uff0c\u663e\u8457\u63d0\u5347\u86cb\u767d\u8d28\u7ec4\u548cN-\u7cd6\u86cb\u767d\u8d28\u7ec4\u5206\u6790\u6548\u7387\uff0c\u5e76\u670d\u52a1\u201c\u79d1\u6280\u51ac\u5965\u201d\u91cd\u5927\u4efb\u52a1\uff08Front Chem, 2021\uff09\uff1b\u63d0\u51fa\u86cb\u767d\u4fee\u9970\u65f6\u7a7a\u53ef\u63a7\u8c03\u8282\u7b56\u7565\uff0c\u5b9e\u73b0\u7ec6\u80de\u5185\u7279\u5b9a\u4fee\u9970\u7684\u7cbe\u51c6\u64cd\u63a7\u4e0e\u529f\u80fd\u9a8c\u8bc1\uff08J Am Chem Soc, 2022\uff09\u3002\u5f53\u524d\u5de5\u4f5c\u8fdb\u4e00\u6b65\u5411\u8d85\u5fae\u91cf\u4f53\u7cfb\u62d3\u5c55\uff0c\u6b63\u5728\u5f00\u53d1\u9762\u5411\u539f\u4ee3\u7ec6\u80de\u7684\u9ad8\u7075\u654f\u5355\u7ec6\u80de\u86cb\u767d\u8d28\u7ec4\u6280\u672f\uff0c\u4ee5\u53ca\u7a7a\u95f4\u86cb\u767d\u8d28\u7ec4\u89e3\u5377\u79ef\u7b56\u7565\uff0c\u5b9e\u73b0\u590d\u6742\u7ec4\u7ec7\u4e2d\u7ec6\u80de\u7c7b\u578b\u4e0e\u5206\u5b50\u4fe1\u53f7\u7684\u5206\u79bb\u4e0e\u91cd\u5efa\uff08\u5728\u7814\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4ee3\u8868\u4f5c\uff1a<br \/>\n1. Fan Z, Li J, Liu T, et al. A new tandem enrichment strategy for the simultaneous profiling of O\u2011GlcNAcylation and phosphorylation in RNA\u2011binding proteome. Analyst, 2021, 146(4): 1188\u20111197.<br \/>\n2. Fan Z, Liu T, Zheng F, et al. An ultra\u2011fast N\u2011glycoproteome analysis method using thermoresponsive magnetic fluid\u2011immobilized enzymes. Frontiers in Chemistry, 2021, 9: 676100.<br \/>\n3. Yang N#, Fan Z#, Sun S, et al. Discovery of highly potent and selective KRAS\u1d33\u00b9\u00b2\u1d9c degraders by VHL\u2011recruiting PROTACs for the treatment of tumors with KRAS\u1d33\u00b9\u00b2\u1d9c mutation. European Journal of Medicinal Chemistry, 2023, 261: 115857.<br \/>\n4. He J#, Fan Z#, Tian Y#, et al. Spatiotemporal activation of protein O\u2011GlcNAcylation in living cells. Journal of the American Chemical Society, 2022, 144(10): 4289\u20114293.<br \/>\n5. Li P#, Hu X#, Fan Z#, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation. Journal of Hematology &amp; Oncology, 2024, 17(1): 77.<\/p>","protected":false},"featured_media":1365,"template":"","member_cat":[],"class_list":["post-1386","member","type-member","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member\/1386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member"}],"about":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/types\/member"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/media\/1365"}],"wp:attachment":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/media?parent=1386"}],"wp:term":[{"taxonomy":"member_cat","embeddable":true,"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member_cat?post=1386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}