{"id":1378,"date":"2026-06-15T14:27:42","date_gmt":"2026-06-15T06:27:42","guid":{"rendered":"http:\/\/cnhupo.org.cn\/?post_type=member&#038;p=1378"},"modified":"2026-06-15T14:27:42","modified_gmt":"2026-06-15T06:27:42","slug":"lin-bai","status":"publish","type":"member","link":"http:\/\/cnhupo.org.cn\/zh\/member\/lin-bai\/","title":{"rendered":"\u767d\u7433"},"content":{"rendered":"<p>\u767d\u7433\u535a\u58eb\u4e8e2018\u5e749\u6708\u81f32024\u5e746\u6708\u5728\u590d\u65e6\u5927\u5b66\u751f\u7269\u5316\u5b66\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u4e13\u4e1a\u653b\u8bfb\u535a\u58eb\u5b66\u4f4d\uff1b2024\u5e7412\u6708\u8d77\u5728\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u4eba\u6c11\u533b\u9662\u62c5\u4efb\u9752\u5e74PI\u3002\u767d\u7433\u535a\u58eb\u73b0\u4e3a\u72ec\u7acb\u9752\u5e74PI\uff0c\u957f\u671f\u4ece\u4e8b\u86cb\u767d\u8d28\u7ec4\u5b66\u4e0e\u86cb\u767d\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\uff0c\u4e3b\u8981\u805a\u7126\u4e8e\u8840\u6d46\u86cb\u767d\u8d28\u7ec4\u6807\u5fd7\u7269\u53d1\u73b0\u3001\u80bf\u7624\u5206\u5b50\u5206\u578b\u4e0e\u7597\u6548\u9884\u6d4b\u3001DNA\u4fee\u9970\u8bc6\u522b\u86cb\u767d\u7cfb\u7edf\u9274\u5b9a\u53ca\u80bf\u7624\u514d\u75ab\u8c03\u63a7\u673a\u5236\u5f00\u5c55\u7cfb\u7edf\u6027\u5de5\u4f5c\uff0c\u81f4\u529b\u4e8e\u63a8\u52a8\u86cb\u767d\u8d28\u7ec4\u5b66\u5728\u80bf\u7624\u7cbe\u51c6\u8bca\u7597\u4e2d\u7684\u8f6c\u5316\u5e94\u7528\u3002\u8fd1\u5e74\u6765\u4ee5\u7b2c\u4e00\/\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u5728Nature Biomedical Engineering\u3001Advanced Science\u3001Nature Immunology\u3001Nature Communications\u7b49\u671f\u520a\u53d1\u8868\u591a\u7bc7\u8bba\u6587\uff0c\u5efa\u7acb\u4e86\u6cdb\u764c\u8840\u6d46\u86cb\u767d\u8d28\u7ec4\u5206\u6790\u7b56\u7565\uff0c\u89e3\u6790\u4e86\u900f\u660e\u7ec6\u80de\u80be\u764cTKI\u5e94\u7b54\u7684\u86cb\u767d\u57fa\u56e0\u7ec4\u5b66\u7279\u5f81\uff0c\u7cfb\u7edf\u7ed8\u5236DNA\u4fee\u9970reader\u8c31\uff0c\u5e76\u63ed\u793a\u4e73\u9170\u5316\u8c03\u63a7NK\u7ec6\u80de\u529f\u80fd\u7b49\u65b0\u673a\u5236\uff0c\u76f8\u5173\u6210\u679c\u517c\u5177\u521b\u65b0\u6027\u3001\u673a\u5236\u6df1\u5ea6\u548c\u8f6c\u5316\u6f5c\u529b\u3002<\/p>\n<p>\u4ee3\u8868\u4f5c\uff1a<br \/>\n1. Bai L*, Lyu J*, Feng J*, Qiao X*, Qu Y*, Yang G*, Zhu Y*, Liao L*, Gao H, Zang A, Xu Z, Ji T, Ran P, Ding W, Zhang H, Zhu L, Wang Y, Wang L, Wang X, Li Y, Li J, Yin X, Zhao G, Liu D, Gao X, Tian S, Tan S, Pu Y, Li L, Song Z, Song J, Guo W, Liao Y#, Ye D#, Yang W#, Jia Y#, Ding C#. Cancer biomarkers discovered using pan-cancer plasma proteomic profiling. Nat Biomed Eng. 2025 Jul 2. doi: 10.1038\/s41551-025-01448-y. PMID: 40603747 (co-first author, equal contribution).<br \/>\n2. Bai L, Yang G, Qin Z, Lyu J, Wang Y, Feng J, Liu M, Gong T, Li X, Li Z, Li J, Qin J, Yang W#, Ding C#. Proteome-Wide Profiling of Readers for DNA Modification. Adv Sci (Weinh). 2021 Oct;8(19): e2101426. doi: 10.1002\/advs.202101426. Epub 2021 Aug 5. PMID: 34351703; PMCID: PMC8498917 (co-first author, equal contribution).<br \/>\n3. Zhang H*, Bai L*, Wu XQ*, Tian X*, Feng J*, Wu X*, Shi GH*, Pei X*, Lyu J*, Yang G, Liu Y, Xu W, Anwaier A, Zhu Y, Cao DL, Xu F, Wang Y, Gan HL, Sun MH, Zhao JY#, Qu Y#, Ye D#, Ding C#. Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor. Nat Commun. 2023 Jul 17;14(1):4274. doi: 10.1038\/s41467-023-39981-6. PMID: 37460463; PMCID: PMC10352361 (co-first author, equal contribution).<br \/>\n4. Lyu J*, Bai L*, Li Y*, Wang X*, Xu Z, Ji T, Yang H, Song Z, Wang Z, Shang Y, Ren L, Li Y, Zang A, Jia Y#, Ding C#. Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy. Nat Commun. 2024 May 8;15(1):3860. doi: 10.1038\/s41467-024-47835-y. PMID: 38719824; PMCID: PMC11078984 (co-first author, equal contribution).<br \/>\n5. Jin J*, Yan P*, Wang D*, Bai L*, Liang H, Zhu X, Zhu H, Ding C#, Wei H#, Wang Y#. Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment. Nature Immunology. 2025 Jul;26(7):1099-1112. doi: 10.1038\/s41590-025-02178-8. Epub 2025 Jun 10. 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