{"id":715,"date":"2025-10-08T00:00:21","date_gmt":"2025-10-07T16:00:21","guid":{"rendered":"http:\/\/cnhupo.org.cn\/?post_type=council_member&#038;p=715"},"modified":"2026-04-29T15:01:22","modified_gmt":"2026-04-29T07:01:22","slug":"chuanqizhong","status":"publish","type":"council_member","link":"http:\/\/cnhupo.org.cn\/zh\/council-member\/chuanqizhong\/","title":{"rendered":"\u949f\u4f20\u5947"},"content":{"rendered":"<p>\u7814\u7a76\u9886\u57df\uff1a<br \/>\n1.\u86cb\u767d\u7ec4\u5b66\u65b9\u6cd5\u7684\u5f00\u53d1\uff1a\u86cb\u767d\u7ec4\u5b66\u662f\u7814\u7a76\u751f\u7269\u6837\u54c1\u4e2d\u6240\u6709\u86cb\u767d\u7684\u529f\u80fd\u72b6\u6001\u7684\u5b66\u79d1\uff0c\u5b83\u5206\u4e3a\u6837\u54c1\u524d\u5904\u7406\uff0c\u8d28\u8c31\u6570\u636e\u91c7\u96c6\u548c\u8d28\u8c31\u6570\u636e\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u4e09\u4e2a\u90e8\u5206\u3002\u5176\u4e2d\uff0c\u6211\u4eec\u5f00\u53d1\u4e86\u6570\u636e\u4e0d\u4f9d\u8d56\u8d28\u8c31\uff08Data-independent acquisition mass spectrometry, DIA-MS\uff09\u6570\u636e\u7684\u7b97\u6cd5\uff08Nature Methods, 2015\uff09,\u6b64\u7b97\u6cd5\u53ef\u4ee5\u4e0d\u4f9d\u8d56\u4e8e\u6570\u636e\u4f9d\u8d56\u8d28\u8c31\uff08Data-dependent acquisition mass spectrometry, DDA-MS\uff09\u800c\u53ef\u76f4\u63a5\u5206\u6790DIA-MS\u6570\u636e\u3002\u6b64\u5916\u6211\u4eec\u5f00\u53d1\u4e86\u57fa\u4e8eSDS\u7684\u86cb\u767d\u7ec4\u5b66\u6837\u54c1\u5236\u5907\u65b9\u6cd5SCASP (MCP, 2021)\u4ee5\u53ca\u65e0\u9700\u8131\u76d0\u65b9\u6cd5\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\u5bcc\u96c6\u65b9\u6cd5SCASP-PTM (Cell Reports, 2025).<br \/>\n2.\u5148\u5929\u514d\u75ab\u548c\u80bf\u7624\u514d\u75ab\u4fe1\u53f7\u901a\u8def\u5206\u5b50\u673a\u5236\u7814\u7a76\uff1a\u6211\u4eec\u6574\u5408\u81ea\u4e3b\u7814\u53d1\u7684\u86cb\u767d\u7ec4\u5b66\u6280\u672f\u4e0e\u9ad8\u901a\u91cfCRISPR\/Cas9\u7b5b\u9009\u5de5\u5177\uff0c\u7cfb\u7edf\u89e3\u6790\u4fe1\u53f7\u901a\u8def\u4e2d\u5173\u952e\u7684\u8c03\u63a7\u673a\u5236\u3002\u5229\u7528SCASP-PTM\u65b9\u6cd5\u5206\u6790\u4e86RNA\u7c7b\u4f3c\u7269poly(I:C)\u523a\u6fc0HeLa-S3\u7ec6\u80de\u7684\u86cb\u767d\u3001\u6cdb\u7d20\u5316\u4fee\u9970\u3001\u78f7\u9178\u5316\u4fee\u9970\u548c\u7cd6\u57fa\u5316\u4fee\u9970\u7684\u53d8\u5316\uff0c\u53d1\u73b0poly(I:C)\u8bf1\u5bfcGSK3B\u4ecb\u5bfc\u7684p62\u86cb\u767d28\u4f4d\u78f7\u9178\u5316\uff0c\u8fdb\u800c\u8bf1\u53d1TNFAIP1\u4ecb\u5bfc\u7684420\u4f4d\u8d56\u6c28\u9178\u6cdb\u7d20\u5316\uff0c\u6700\u7ec8\u5bfc\u81f4p62\u964d\u89e3\u5e76\u51cf\u5f31\u7ec6\u80de\u81ea\u566c (Cell Reports, 2025)\u3002\u6b64\u5916\uff0c\u5229\u7528SCASP-PTM\u65b9\u6cd5\u5206\u6790\u4e86\u4e34\u5e8a\u80ba\u764c\u548c\u764c\u65c1\u7ec4\u7ec7\u7684\u603b\u86cb\u767d\u3001\u6cdb\u7d20\u5316\u4fee\u9970\u3001\u4e59\u9170\u5316\u4fee\u9970\u3001\u78f7\u9178\u5316\u4fee\u9970\u548c\u7cd6\u57fa\u5316\u4fee\u9970\u7684\u53d8\u5316\uff0c\u63ed\u793a\u4e86ALDOA\u7684K330\u7684\u4e59\u9170\u5316\u4fee\u9970\u548c\u6cdb\u7d20\u5316\u4fee\u9970\u4fc3\u8fdb\u4e86\u80bf\u7624\u7684\u53d1\u5c55 (Cell Reports, 2025)\u3002<\/p>\n<p>\u4ee3\u8868\u8bba\u6587\uff1a<br \/>\n1. Lin ZP, Gan G, Xu X, Wen C, Ding X, Chen XY, Zhang K, Guo WY, Lin M, Wang YY, Chen X, Xie C, Wang J*, Li M*, Zhong CQ*. Comprehensive PTM profiling with SCASP-PTM uncovers mechnisms of p62 degradation and ALDOA-mediated tumor progression. Cell Rep. 2025 Apr 3;44(4):115500. Doi: 10.1016\/j.celrep.2025.115500. (IF=7.5)<br \/>\n2. Wen C, Wu X*, Lin G, Yan W, Gan G, Xu X, Chen XY, Chen X, Liu X, Fu G*, Zhong CQ*. Evaluation of DDA Library-Free Strategies for Phosphoproteomics and Ubiquitinomics Data-Independent Acquisition Data. J Proteome Res. 22, 2232-2245 (2023). (IF=5.3)<\/p>","protected":false},"featured_media":714,"template":"","member_category":[],"class_list":["post-715","council_member","type-council_member","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/council_member\/715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/council_member"}],"about":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/types\/council_member"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/media\/714"}],"wp:attachment":[{"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/media?parent=715"}],"wp:term":[{"taxonomy":"member_category","embeddable":true,"href":"http:\/\/cnhupo.org.cn\/zh\/wp-json\/wp\/v2\/member_category?post=715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}