于晓波 Xiaobo Yu

研究方向：从事蛋白质组学芯片技术和精准医学研究。成功开发以人类、肺结核和新冠病毒为代表的系列蛋白质组学芯片（美国化学会经典案例）；建立第一个人类自身抗原数据库并揭示自身抗原形成规律（Hallmarks of Human Autoantigens）；领导肺癌和淋巴瘤等中西医临床队列蛋白质组学研究,发现十余个原创标志物。

Research Direction: Engaged in proteomics chip technology and precision medicine research. Successfully developed a series of proteomics chips represented by human, tuberculosis and COVID-19 viruses (classic case of the American Chemical Society); established the first human autoantigen database and revealed the formation patterns of autoantigens (Hallmarks of Human Autoantigens); led proteomics research in Chinese and Western medicine clinical cohorts for lung cancer and lymphoma, discovering more than ten original biomarkers.

1. Cheng L#, Wang D#, Wang Z#, Li H, Wang G, Wu Z, Xu M, Yan S, Zhan H, Wang H, Zhang X, Liang T, Wei C, Zhang F, Zheng W*, Yu X*, Li Y*. Proteomic landscape mapping of organ-resolved Behçet’s disease using in-depth plasma proteomics for identifying HABP2 expression associated with vascular damage. Arthritis & Rheumatology. 2023 Mar;75(3):424-437.
2. Zhang X#, Zheng M#, Wang H, Zhou H, Liang T, Zhang J, Ren J, Peng H, Li S, Bian H, Wei C, Yin S, He C, Han Y, Li M, Hou X, Zhang J, Xie L, Lv J, Kan B*, Wang Y*, Yu X*. Inhibitor screening of Spike variants reveals the heterogeneity of neutralizing antibodies to COVID-19 infection and vaccination. Theranotics.2022 12(6):2519-2534.
3. Yang L#, Liang T#, Pierson LM, Wang H, Fletcher JK, Wang S, Bao D, Zhang L, Huang Z, Zheng W, Zhang X, Park H, Li Y, Robinson JE, Feehan AK, Lyon CJ, Cao J, Morici LA, Li C, Roy CJ, Yu X*, Hu T*. SARS-CoV-2 infection and vaccination linear epitopes overlap known neutralizing antibody sites. Research (Wash D C). 2022:9769803.
4. Yu X*,,et al.. Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients. Signal Transduction and Targeted Therapy. 2021 6(1):304.