叶明亮 Mingliang Ye

主要从事分析化学新方法及其在生命健康领域的应用研究。课题组以色谱分离与质谱分析为立足点,针对蛋白质组等复杂生物样品的高效分离与高灵敏检测问题,开展色谱、质谱分析新技术和新方法及其在生物医学中的应用的研究,注重解决疾病蛋白质组学研究所面临的技术瓶颈问题,让精准医学更精准。课题组在蛋白质组学分析,尤其是翻译后修饰蛋白质组学分析、药物靶标蛋白质鉴定等方面建立了多种独创的分析方法。

Mainly engaged in research on new methods of analytical chemistry and their applications in the field of life and health. The research group focuses on chromatographic separation and mass spectrometry analysis, conducts research on new chromatographic and mass spectrometry analysis technologies and methods and their applications in biomedicine, targeting the efficient separation and highly sensitive detection of complex biological samples such as proteomes, with emphasis on solving technical bottleneck problems faced by disease proteomics research, making precision medicine more precise. The research group has established various original analysis methods in proteomics analysis, especially post-translational modification proteomics analysis and drug target protein identification.

A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands
Kejia Li, Shijie Chen, Keyun Wang, Yan Wang, Lianji Xue, Yuying Ye,Zheng Fang , Jiawen Lyu, Haiyang Zhu, Yanan Li, Ting Yu, Feng Yang, Xiaolei Zhang, Siqi Guo, Chengfei Ruan, Jiahua Zhou, Qi Wang, Mingming Dong , Cheng Luo, Mingliang Ye
Nature Methods, 2024, 1-17
Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers
Keyun Wang, Li Zhang, Sirui Zhang, Ye Liu, Jiawei Mao, Zhen Liu, Lin Xu, Kejia Li, Jianshu Wang, Yanni Ma, Jiayi Wang, Haitao Li, Zefeng Wang, Guohui Li, Hong Cheng, Mingliang Ye
Nature Communications, 2024, 15:7459, 1-14
A Chemoenzymatic Method Enables Global Enrichment and Characterization of Protein Arginine Methylation
Jiayi Wang, Qi Wang, Jiahua Zhou, Yan Wang, Zhen Liu, Keyun Wang, Mingliang Ye
Analytical Chemistry, 2024, 96, 14612−14620
Robust Glycoproteomics Platform Reveals a Tetra-Antennary Site-Specific Glycan Capping with Sialyl-Lewis Antigen for Early Detection of Gastric Cancer
Luyao Liu, Lei Liu, Yan Wang, Zheng Fang, Yangyang Bian, Wenyao Zhang, Zhongyu Wang, Xianchun Gao, Changrui Zhao, Miaomiao Tian, Xiaoyan Liu, Hongqiang Qin, Zhimou Guo, Xinmiao Liang, Mingming Dong, Yongzhan Nie, Mingliang Ye
Advanced Science, 2023, 2306955, 1-14