贾立军 Lijun Jia

研究方向：抗肿瘤分子靶点发现与中西医靶向干预策略研究
1. 新型抗癌分子靶标发现与药物筛选
2. 临床抗癌中药有效成分与作用机制
3. 情志失调致病机理与中医干预策略
4. 节食禁食调控身心健康的效应机制

Research Directions: Discovery of anti-tumor molecular targets and integrated Chinese-Western medicine targeted intervention strategies
1. Discovery of novel anticancer molecular targets and drug screening
2. Active components and mechanisms of action of clinical anticancer Chinese medicines
3. Pathological mechanisms of emotional disorders and Traditional Chinese Medicine intervention strategies
4. Mechanisms of dietary restriction and fasting in regulating physical and mental health

1. Zhu F, Li L, Chen Y, Pan Y, Zhang W, Li L, Cai L, Zhao X, Zhao H, Wang S, Jia L. CRL3Keap1 E3 ligase facilitates ubiquitin-mediated degradation of oncogenic SRX to suppress colorectal cancer progression. Nat Commun. 2024 Dec 3;15(1):10536.
2. Liang Y, Chen P, Wang S, Cai L, Zhu F, Jiang Y, Li L, Zhu L, Heng Y, Zhang W, Pan Y, Wei W, Jia L. SCFFBXW5-mediated degradation of AQP3 suppresses autophagic cell death through the PDPK1-AKT-MTOR axis in hepatocellular carcinoma cells. Autophagy. 2024 Sep;20(9):1984-1999.