张迪 Di Zhang

张迪，北京大学生命科学学院助理教授，北京大学博雅青年学者、基因功能研究与操控全国重点实验室、北大-清华生命科学联合中心研究员。从事代谢适应与代谢调控的信号转导机制研究。张迪研究员毕业于北京大学基础医学院八年制，师从尚永丰院士，从事表观遗传与基因转录调控在肿瘤发生发展中的分子机制研究；在芝加哥大学开展博士后研究工作，与Louis Block 讲席教授赵英明合作，首次发现哺乳动物细胞中代谢产物（如乳酸、酮体等）可以驱动新型蛋白质修饰——赖氨酸乳酰化修饰等，目前已被引用超过2000次。

Zhang Di, Assistant Professor at the School of Life Sciences, Peking University, Peking University Boya Young Scholar, Researcher at the National Key Laboratory of Gene Function Research and Manipulation, and Peking University-Tsinghua University Joint Center for Life Sciences. She is engaged in research on signal transduction mechanisms of metabolic adaptation and metabolic regulation. Researcher Zhang Di graduated from the eight-year program of Peking University Health Science Center, studying under Academician Shang Yongfeng, and was engaged in research on the molecular mechanisms of epigenetics and gene transcriptional regulation in tumor occurrence and development. During her postdoctoral research at the University of Chicago, in collaboration with Louis Block Chair Professor Zhao Yingming, she first discovered that metabolites in mammalian cells (such as lactate, ketone bodies, etc.) can drive novel protein modifications—lysine lactylation modifications, etc., which have now been cited over 2,000 times.

(*Co-first author, # Corresponding author)
(1) Ren H, Tang Y, Zhang D#. (2025).The emerging role of protein l-lactylation in metabolic regulation and cell signalling. Nat Metab 7: 647–664.
(2) Zhang D#, Gao J, Zhu Z, Mao Q, Xu Z, Singh PK, Rimayi CC, Moreno-Yruela C, Xu S, Li G, Sin YC, Chen Y, Olsen CA, Snyder NW, Dai L, Li L, Zhao Y. (2025). Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis. Nat Chem Biol. 21(1): 91–99.
(3) Ren H, Zhang D#. (2024). Lactylation constrains OXPHOS under hypoxia. Cell Res. 34(2): 91-92.
(4) Gao J, Sheng X, Du J, Zhang D, Han C, Chen Y, Wang C, Zhao Y. (2023). Identification of 113 new histone marks by CHiMA, a tailored database search strategy. Sci Adv. 9(14): eadf1416.
(5) Moreno-Yruela C, Zhang D*, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y. (2022). Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Sci Adv. 8(3): eabi6696.
(6) Huang H, Zhang D*, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y. (2021). The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway. Sci Adv. 7(9): eabe2771.
(7) Zhang D*, Tang Z*, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman H, Ding J, Dai L, Ren B, Robert RG, Becker L, Zhao Y. (2019). Metabolic regulation of gene expression by histone lactylation. Nature. 574: 575-580.
(8) Huang H, Zhang D, Wang Y, Perez-Neut M, Han Z, Zheng YG, Hao Q, Zhao Y. (2018). Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 9(1): 3374.
(9) Sabari BR*, Zhang D*, Allis CD, Zhao Y. (2017). Metabolic Regulation of Gene Expression through Differential Histone Acylation. Nat Rev Mol Cell Biol. 18(2): 90-101.
(10) Xie Z*, Zhang D*, Chung D*, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y. (2016). Metabolic Regulation of Gene Expression by Histone Lysine beta-hydroxybutyrylation. Mol Cell. 62(2): 194-206.
(11) Goudarzi A*, Zhang D*, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S. (2016). Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Mol Cell. 62(2): 169-80.
(12) Zhang Y*, Zhang D*, Liang J, Yi X, Gui B, Yu W, Sun L, Yang X, Han X, Chen Z, Liu S, Si W, Yan R, Wang Y, Shang Y. (2016). Nucleation of DNA Repair Factors by FOXA1 Links DNA Demethylation to Transcriptional Pioneering. Nat Genet. 48(9): 1003-13.