汪迎春 Yingchun Wang

研究方向：1.运动细胞的蛋白质组学 – 细胞在外界化学因子的诱导下会产生形态变化和定向运动（Chemotaxis or Directional cell migration）。这个反应对生物生长发育过程中的一些重要的生理及病理过程起着至关重要的作用。如癌细胞的转移与扩散就是一种定向性细胞运动。我们将应用功能蛋白质组学研究运动细胞(包括癌细胞和神经细胞)在运动过程中的形态控制和信号转导机制，并找出控制细胞运动的关键性蛋白和关键性翻译后修饰，为与细胞运动相关的疾病的诊断和治疗提供靶标。2. 生物信息学及计算生物学 – 我们的生物信息及计算生物学研究主要是用来服务蛋白质组学研究。我们将开发一些应用软件来处理大规模的蛋白质组学数据和进行功能性预测。同时我们建立一个关于蛋白质磷酸化位点的网络数据库 (a web-based relational database)。这个数据库将包括磷酸化位点的功能和量化方面的信息。预计这个数据库对于预测蛋白磷酸化信息与细胞的生物学表型之间的联系起到重要的作用。3.生物膜的功能蛋白质组学 – 生物膜含有多种蛋白，包括各种受体，通道，以及具有催化活性的酶。膜蛋白对于生物的生长，发育，以及对外界环境变化的应答起着极其重要的作用。然而由于膜蛋白的不溶性，对它们的研究远远落后于对可溶性蛋白的研究。我们近期将利用光合蓝藻的thylakoid membrane作为材料，进行膜蛋白的功能蛋白质组学和生物信息学研究。未来我们还将开展动物细胞生物膜的功能蛋白质组学研究。

Research Interests: 1. Proteomics of Motile Cells – Cells undergo morphological changes and directional movement (Chemotaxis or Directional cell migration) induced by external chemical factors. This response plays a crucial role in important physiological and pathological processes during biological growth and development. For example, cancer cell metastasis and dissemination is a type of directional cell movement. We apply functional proteomics to study the morphological control and signal transduction mechanisms of motile cells (including cancer cells and nerve cells) during movement, and identify key proteins and critical post-translational modifications controlling cell movement to provide targets for diagnosis and treatment of diseases related to cell movement. 2. Bioinformatics and Computational Biology – Our bioinformatics and computational biology research primarily serves proteomics research. We will develop application software to process large-scale proteomics data and perform functional predictions. We are also establishing a web-based relational database for protein phosphorylation sites. This database will include information on the function and quantification of phosphorylation sites. It is expected that this database will play an important role in predicting the relationship between protein phosphorylation information and cellular biological phenotypes. 3. Functional Proteomics of Biological Membranes – Biological membranes contain various proteins, including receptors, channels, and enzymes with catalytic activity. Membrane proteins play extremely important roles in biological growth, development, and responses to environmental changes. However, due to the insolubility of membrane proteins, research on them lags far behind that on soluble proteins. We will recently use the thylakoid membrane of photosynthetic cyanobacteria as material to conduct functional proteomics and bioinformatics research on membrane proteins. In the future, we will also carry out functional proteomics research on biological membranes of animal cells.