Zuye Fang
Member
Dr. Fang earned his Ph.D. in Biochemistry and Molecular Biology from Jinan University from September 2018 to June 2024. Since July 2024, he has been a Postdoctoral Researcher at Shenzhen Bay Laboratory. Dr. Fang’s research focuses on the intersection of proteomics and chemical biology. During his doctoral studies, he conducted research on chemical proteomics, drug proteomics, and outer membrane vesicle proteomics, focusing on bacterial resistance and antimicrobial mechanisms. In his postdoctoral stage, he has concentrated on technological innovation in small protein research, developing a flavin-peptide-based photocatalytic proximity labeling platform for dissecting the dynamic interaction networks and functional mechanisms of small proteins such as G proteins and BANF1. His research emphasizes the integration of “technological innovation and mechanistic elucidation,” featuring low-disturbance, high spatiotemporal resolution capture of native small protein interactomes. This work holds significant implications for revealing disease-associated regulatory networks and discovering novel therapeutic intervention targets. Dr. Fang serves as the Principal Investigator of multiple research projects. His representative publications include Journal of Hazardous Materials, Cell Reports, Journal of Antimicrobial Chemotherapy, and mSystems.
Selected publications:
1. Fang Z, Zhao X, Zhang Z, Wu J, Cheng J, Lei D, Li N, Ge R, He QY, Sun X. Unveiling a novel mechanism for competitive advantage of ciprofloxacin‑resistant bacteria in the environment through bacterial membrane vesicles. Journal of Hazardous Materials, 2024, 466: 133453.
2. Zhuang J#, Liu S#, Du GF#, Fang Z#, Wu J, Li N, Zhong T, Xu J, He QY, Sun X. YjgM is a crotonyltransferase critical for polymyxin resistance of Escherichia coli. Cell Reports, 2024, 43(5): 114161.
3. Fang ZY, Zhang ZY, Zheng YD, Lei D, Zhuang J, Li N, He QY, Sun X. Repurposing cinacalcet suppresses multidrug‑resistant Staphylococcus aureus by disruption of cell membrane and inhibits biofilm by targeting IcaR. Journal of Antimicrobial Chemotherapy, 2024, 79(4): 903‑917.
4.Fang Z, Lai F, Cao K, Zhang Z, Cao L, Liu S, Duan Y, Yin X, Ge R, He QY, Sun X. Potential Role of Lysine Acetylation in Antibiotic Resistance of Escherichia coli. mSystems, 2022, 7(6): e0064922.