Zhiya Fan

Dr. Fan earned her Ph.D. in Pharmaceutical Analysis from the Academy of Military Sciences from September 2019 to June 2025. Since December 2025, she has been serving as an Assistant Research Fellow at the Academy of Military Medical Sciences (AMMS) of the PLA Academy of Military Sciences. Dr. Fan’s research focuses on the development of novel proteomic technologies, with an emphasis on the precise characterization of low-abundance functional proteins and their post-translational modifications. She has systematically established a highly sensitive and ultra-fast proteomic technology platform spanning from high-throughput global analysis to single-cell and spatial resolution. She developed a combined enrichment and identification method for O-GlcNAcylation and phosphorylation, enabling coordinated analysis of key modification information (Analyst, 2021). She also developed an ultra-fast sample processing and enzymatic reaction system that significantly improves the efficiency of proteome and N-glycoproteome analysis, and contributed to the major “Tech Winter Olympics” initiative (Front Chem, 2021). In addition, she proposed a spatiotemporally controllable regulation strategy for protein modifications, enabling precise manipulation and functional validation of specific modifications within cells (J Am Chem Soc, 2022). Her current work is further expanding into ultra-trace systems, with ongoing development of highly sensitive single-cell proteomic technologies for primary cells, as well as spatial proteomic deconvolution strategies to achieve the separation and reconstruction of cell types and molecular signals within complex tissues (ongoing research).

Selected publications:
1. Fan Z, Li J, Liu T, et al. A new tandem enrichment strategy for the simultaneous profiling of O‑GlcNAcylation and phosphorylation in RNA‑binding proteome. Analyst, 2021, 146(4): 1188‑1197.
2. Fan Z, Liu T, Zheng F, et al. An ultra‑fast N‑glycoproteome analysis method using thermoresponsive magnetic fluid‑immobilized enzymes. Frontiers in Chemistry, 2021, 9: 676100.
3. Yang N#, Fan Z#, Sun S, et al. Discovery of highly potent and selective KRASᴳ¹²ᶜ degraders by VHL‑recruiting PROTACs for the treatment of tumors with KRASᴳ¹²ᶜ mutation. European Journal of Medicinal Chemistry, 2023, 261: 115857.
4. He J#, Fan Z#, Tian Y#, et al. Spatiotemporal activation of protein O‑GlcNAcylation in living cells. Journal of the American Chemical Society, 2022, 144(10): 4289‑4293.
5. Li P#, Hu X#, Fan Z#, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation. Journal of Hematology & Oncology, 2024, 17(1): 77.