Yingdi Zhu

Dr. Zhu earned her Ph.D. in Chemistry (Mass Spectrometry) from the Swiss Federal Institute of Technology Lausanne (EPFL) from October 2014 to September 2018. She conducted postdoctoral research at EPFL from October 2018 to January 2022, and served as a Visiting Scholar at Stanford University, USA, from March to July 2019. Since November 2022, she has been a Distinguished Research Fellow at the Hangzhou Institute of Medicine, Chinese Academy of Sciences (HIM, CAS). Since 2014, Dr. Zhu has been engaged in mass spectrometry-based protein analysis for disease diagnostics, accumulating nearly 12 years of experience in the field of mass spectrometry proteomics. Her current work focuses on the early diagnosis of pancreatic cancer (as part of the CAS Strategic Priority Research Program B), developing novel methodologies including metaproteomics, chemical labeling proteomics, chemistry-assisted spatial proteomics, and trace-sample proteomics, aiming to discover protein biomarkers for early pancreatic cancer detection from minimally invasive samples such as blood and feces.

Selected publications:
1. Yingdi Zhu; Horst Pick; Natalia Gasilova; Xiaoyun Li; Tzu-En Lin; Heinz Philipp Laeubli; Alfred Zippelius; Ping-Chih Ho; Hubert H. Girault; MALDI Detection of Exosomes: A Potential Tool for Cancer Studies, *Chem*, 2019, 5(5).
2. Yingdi Zhu; Andreas Lesch; Xiaoyun Li; Tzu-En Lin; Natalia Gasilova; Milica Jovic; Horst Matthias Pick; Ping-Chih Ho; Hubert H. Girault; Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning, *JACS Au*, 2021, 1(5): 598-611.
3. Ming Su; Tao Peng; Yingdi Zhu; Juan Li; Nucleic Acid Covalent Tags, *ChemBioChem*, 2024, e202400805: 1-17.
4. Tao Peng; Min Su; Zuying Zhang; Ya Wang; Yinhong Tang; Hang Jiang; Zhiyuan Peng; Yingdi Zhu; Juan Li; Aptamer-Directed Dual-Site Photoaffinity Labeling Enables Functional Regulation of Protein–Protein Interactions, *CCS Chemistry*, 2025, 025(202506176).
5. Zhilan Zhou; Yichang Liu; Ya Wang; Hang Jiang; Tingting Chen; Yingdi Zhu; Ting Fu; Juan Li; Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance, *Nature Communications*, 2025, 16(1).