Xing Chen

Research Interests: Focused on chemical glycobiology and bio-nanotechnology. Utilizing chemical methods, biological approaches, and nanotechnology to study the biological functions of glycosylation and its roles in metabolic diseases and cardiovascular complications. Main research areas include: 1) Chemical labeling of glycans in living cells and organisms; 2) Synthesis, imaging, and omics analysis of glycans; 3) Functions of glycosylation in the nervous system and stem cells; 4) Intrinsic connections between glycometabolism and glycosylation; 5) Chemical biology techniques based on bioorthogonal reactions.

Li, W., Gao, L., Cui, S., Wei, T., Sun, J., Zhou, X., Liang, S., Pan, X., Pan, X., Gao, C., Wang, Y., Chang, J., Wang, C., Lv, P., Xiao, J., Dai, P., & Chen, X. (2025). Protein β-O-glucosylation by Legionella LtpM through short consensus sequons G-T/S and S-G. Nature chemical biology, 10.1038/s41589-025-01968-3. Advance online publication.

Liang, S., Tang, Q., Guo, X., Li, Z., Guo, Y., Chang, J., Cheng, B., Song, Q., Sun, J., Dai, P., & Chen, X. (2025). Mutant glycosidases for labeling sialoglycans with high specificity and affinity. Nature communications, 16(1), 1427.

Zhang, X., Tang, Q., Sun, J., Guo, Y., Zhang, S., Liang, S., Dai, P., & Chen, X. (2023). Cellular-scale proximity labeling for recording cell spatial organization in mouse tissues. Science advances, 9(21), eadg6388.