赖仞 Ren Lai

委员 Member

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研究方向：天然药物功能蛋白质组
方向一：动物毒素及功能多样性。开展毒素多组学分析，鉴定毒素分子种类及丰度，构建有毒动物毒液资源数据库。研究动物毒素通过干预猎物或者捕食者神经、免疫、循环、呼吸、运动等基本生命系统而发挥捕食或防御等功能。
方向二：动物毒素介导的物种互作与协同演化。研究毒素驱动种内、种间竞争的作用靶点和协同演化。研究毒素被第三方（如微生物）利用而实施生存适应，揭示毒素复杂的生态学角色。
方向三：以动物毒素为工具探索生理病理机制及研发创新药物。利用毒素探索动物和人类对温度、疼痛、高海拔感知、响应及血栓、感染、抑郁、慢性炎症等生理、病理机制，并基于新机制发现和研究创新药物。

Research Direction: Functional Proteomics of Natural Medicines
Direction 1: Animal toxins and functional diversity. Conducting multi-omics analysis of toxins, identifying toxin molecular types and abundances, and constructing databases of venomous animal venom resources. Studying how animal toxins exert predation or defense functions by interfering with basic life systems such as the nervous, immune, circulatory, respiratory, and motor systems of prey or predators.
Direction 2: Species interactions and co-evolution mediated by animal toxins. Studying the action targets and co-evolution of toxin-driven intraspecific and interspecific competition. Investigating how toxins are utilized by third parties (such as microorganisms) for survival adaptation, revealing the complex ecological roles of toxins.
Direction 3: Using animal toxins as tools to explore physiological and pathological mechanisms and develop innovative drugs. Using toxins to explore the physiological and pathological mechanisms of animals and humans in perceiving and responding to temperature, pain, high altitude, as well as thrombosis, infection, depression, chronic inflammation, etc., and discovering and researching innovative drugs based on new mechanisms.

1. Fang M, Li Y, Liao Z, Wang G, Cao Q, Li Y, Duan Y, Han Y, Deng X, Wu F, Kamau PM, Lu Q, Lai R. Lipopolysaccharide-binding protein expression is increased by stress and inhibits monoamine synthesis to promote depressive symptoms. Immunity. 2023;56(3):620-634.e11.
2. Jin L, Jiang BG, Yin Y, Guo J, Jiang JF, Qi X, Crispell G, Karim S, Cao WC, Lai R. Interference with LTβR signaling by tick saliva facilitates transmission of Lyme disease spirochetes. Proc Natl Acad Sci U S A. 2022;119(47):e2208274119.